A randomized comparative control study on effects of dexmedetomidine versus dexamethasone on the incidence of postoperative nausea and vomiting in patients undergoing laparoscopic surgery under general anaesthesia.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 105
- Locations
- 1
- Primary Endpoint
- To evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately.
Study Overview
Brief Summary
This study is a randomized,double blinded, parallel group, single centre trial evaluating and comparing the efficacy of intravenous dexmethasone and intravenous dexmedetomidine on incidence of post opearative nausea and vomiting in patients undergoing laproscopic surgeries under general anaesthesia. the primary outcome will be to evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately. secondary outcomes will be to compare and evaluate incidence of rescue antiemetic used with dexmedetomidine and dexamethasone,to compare and evaluate side effects of dexmedetomidine and dexamethasone,to compare and evaluate patient satisfaction with Post-opeartive Nausea and vomiting.
Study Design
- Study Type
- Interventional
- Allocation
- Random Number Table
- Masking
- Participant and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients of ASA physical status I and II, both gender in the mentioned age group who will give written informed consent.
Exclusion Criteria
- •Patients with ASA physical status III of greater.
- •Severe cardiorespiratory,hepatic,renal,neurological or endocrinal disease.
- •Bradycardia(Heart Rate<60bpm).
- •Pregnant and lactating women.
- •Obesity(BMI>30kg/m2).
- •Diabetes mellitus.
- •Patientswith known hypersensivity of drug allergies.
- •Patients who had taken H2 antagonists,antiemetic or psychoactive medication.
- •Nausea, retching,or vomiting within 48hours before surgery.
- •History of Motion sickness.
- •Patients who refuse to participate in the study.
Outcomes
Primary Outcomes
To evaluate and compare complete response to and/or incidence of Post operative nausea and vomiting with dexmedetomidine and dexamethasone seperately.
Time Frame: Baseline | Before Administration Of Drug | After administration of Drug | During Intubation | After Intubation | 45 mins Intraoperatively | At the end of Surgery | 15 minutes postoperatively | 2 hours postoperatively | 6 hours postoperatively | 12 hours postoperatively
Secondary Outcomes
- To compare and evaluate incidence of rescue antiemetic used with dexmedetomidine and dexamethasone.(To compare and evaluate side effects of dexmedetomidine and dexamethasone.)