Differential Effects of a Diet Supplementation With Plant Sterol Esters on Human Monocytes

Not Applicable

• Conditions: Hyperlipidemia
• Interventions: Dietary Supplement: margarine + plant sterol esters; Dietary Supplement: margarine (placebo)

• Registration Number: NCT00928616
• Lead Sponsor: University Hospital, Saarland

Brief Summary

The purpose of this study is to evaluate the effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

Detailed Description

This study investigates effects of a diet supplementation with plant sterol esters on serum lipids, plant sterol concentrations and monocyte subpopulations.

Study Timeline

• Study Start: 2009-04
• Status Verified: 2009-06
• Primary Completion: 2009-06
• Study Completion: 2009-06
• Study First Submitted: 2009-06-25
• Study First Submitted QC: 2009-06-25
• Last Update Submitted: 2009-06-25
• Study First Posted: 2009-06-26
• Last Update Posted: 2009-06-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• healthy individuals without known cardiovascular diseases

Exclusion Criteria

• drugs that interfere with cholesterol metabolism
• other use of dietary supplements
• vegetarianism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
plant sterol esters	margarine + plant sterol esters	Participants consume plant sterol ester supplemented margarine (3 g/day)
Placebo	margarine (placebo)	Placebo is a non-sterol ester supplemented margarine

Primary Outcome Measures

Name	Time	Method
monocyte subpopulations	4 weeks

Secondary Outcome Measures

Name	Time	Method
serum parameters (lipids, plant sterol concentrations, inflammation parameters)	4 weeks

Trial Locations

Locations (1)

Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III; 🇩🇪 Homburg, Saarland, Germany