Effects of Fermented Red Clover on Muscle Strength and Muscle Mass

Not Applicable

Completed

• Conditions: Estrogen Deficiency
• Interventions: Dietary Supplement: Red clover; Dietary Supplement: Placebo

• Registration Number: NCT04154306
• Lead Sponsor: University of Aarhus

Brief Summary

The project is designed as a randomized controlled, double-blinded, cross-over trial, including 10 healthy postmenopausal women consuming fermented red clover extract or placebo twice daily over a two-week period. After the first trial (two weeks), participants will undergo a two-week washout period, after which they will receive the opposite trial drink for two weeks. The trial period runs over six weeks. Before each of the two trial rounds, participants will meet in the laboratory and perform muscle strength tests (trial days 1 and 3). After each trial round (trial days 2 and 4), participants will meet fasting in the laboratory, and a blood test and a muscle biopsy will be taken initially. Next, the subject consumes the test drink (placebo or red clover extract) before the subject performs a strength training session with one leg. Right after the training session, the subject consumes a protein drink. Three hours after the protein drink, another muscle biopsy is taken. During the period from the protein drink to the final biopsy, the subject performs two muscle strength tests (respectively grip strength and maximum upper arm muscle strength (biceps)). The primary target parameter is muscle protein signaling measured in the muscle tissue samples using the western blotting method.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-31
• Study Start: 2019-11-01
• Study First Submitted QC: 2019-11-04
• Study First Posted: 2019-11-06
• Primary Completion: 2019-12-17
• Study Completion: 2020-11-01
• Last Update Submitted: 2020-11-03
• Last Update Posted: 2020-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

• maximum of 5 years since last menstrual bleeding
• Minimum of 6 months since last menstrual bleeding

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Exclusion Criteria

• Performed systematic resistance training within the last 6 months
• Smoker
• Using any form of medicine influencing the effects of resistance training

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Red clover	Red clover	-
Placebo	Placebo	-

Primary Outcome Measures

Name	Time	Method
Muscle protein signalling measured by western blotting	Change from pre to 3 hours post training	Change in protein content between two time points

Secondary Outcome Measures

Name	Time	Method
Forearm and biceps strength measured by maximal isometric muscle strength	Change from Pre to post intervention.

Trial Locations

Locations (1)

Aarhus University, Department for Public Health, Section for Sport Science; 🇩🇰 Aarhus, Denmark