Rice Intervention in Chronic Health Study

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Diabetes Arm: Inclusion Criteria: - Attending outpatient clinics - Age 18 - 60 years (i.e. adult population) - Both male and female - Regular consumption of polished white rice (presumably high-GI) = 200g/day - Established T2DM patients on oral medication - Glycated hemoglobin (HbA1c) 7% to 10% - Willing to take part and being compliant to the study protocol Exclusion Criteria: - Glycated hemoglobin (HbA1c) <7% or >10% - Use of insulin - A change in the type of treatment (e.g. insulin injection) during the intervention period - Regular consumption of low-GI rice types (basmati) or colored rice (red rice, purple rice, black rice) for =3 months. - Oral corticosteroids > 3 months - Pregnancy - Unstable medical condition. - Undergone any major operation in the past 3 months - Chronic alcohol drinker. - Not on weight loss diets or supplementation. - Taking part in another clinical trial. Healthy arm: Inclusion Criteria: - Healthy free living - With glycated haemoglobin (HbA1c <6.3%) - Age 18 - 60 years (i.e. adult population) - Both male and female - Regular consumption of polished white rice (presumably high-GI) = 200g/day - Generally, physically and mentally healthy as per medical examination. - Willing to take part and being compliant to the study protocol. Exclusion Criteria: - Regular consumption of low-GI rice types (basmati) or colored rice (red rice, purple rice, black rice) for =3 months - Presence of gastrointestinal disease, metabolic diseases such as diabetes, kidney failure, liver or pancreatic disease, hyperthyroidism, cancer or severe malnutrition. - Oral corticosteroids > 3 months - Pregnancy - Undergone any major operation in the past 3 months - Chronic alcohol drinker. - Not on weight loss diets or supplementation.. - Taking part in another clinical trial.

Exclusion Criteria

Not provided

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in cardio-metabolic parameters;Changes in urinary and plasma metabolome;Changes in mitochondrial DNA methylation and circulating miRNAs expression

Secondary Outcome Measures

Name	Time	Method
Consumer Acceptance Test;Facilitators and Barriers to the Inclusion of UKMRC9 as a staple food;Dietary Pattern of Malaysian Adults with and without diabetes;Diet Quality of Malaysian Adults with and without diabetes;Changes in Advanced Glycation End (AGEs) products measured by skin autofluorescence using AGE Reader mu (Diagnostics).