Impact of Continuous Positive Airway Pressure Therapy on Pulmonary Hypertension and Exercise Capacity in Newly Diagnosed Obstructive Sleep Apnea Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Hypertension
- Sponsor
- Zagazig University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- change of mean pulmonary artery pressure measured by echo
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
All patients are newly diagnosed Obstructive Sleep Apnea patients performing full night polysmnographic sleep study, whose echocardiographic findings elucidate presence of pulmonary hypertension(PH). These patients seemed to have PH if mPAP ≥25 mmHg . All studied patients were received CPAP therapy with average cumulative adherence ⩾4 h/day of >70% nights [380] obtained from device download with AHI<5 /hr
Echocardiography:
It was performed initially to diagnose pulmonary hypertension and repeated after three months of CPAP therapy as a follow up . All enrolled patients were subjected to trans-thoracic echocardiography using Ultrasound system (Vivid I, GE Healthcare, Little Chalfont, UK), with a 2.5 MHz transducer. Certain measurements were then used to calculate mPAP.
Patients were considered to have PH if mPAP ≥25 mmHg, and were classified into mild (20-40 mmHg), moderate (41-55 mmHg), and severe (>55 mmHg) degrees.
Evidence of PH is found by Doppler echocardiography showing an elevated right ventricular systolic pressure (RVSP).
Investigators
Ahmad Abbas
Lecturer of chest diseases
Zagazig University
Eligibility Criteria
Inclusion Criteria
- •All patients are newly diagnosed Obstructive Sleep Apnea patients performing full night polysmnographic sleep study, whose echocardiographic findings elucidate presence of pulmonary hypertension(PH).
Exclusion Criteria
- •Patients aged \< 18 years
- •Patients with secondary PH, due to pulmonary diseases, or left ventricular heart diseases , or chronic thromboembolic disorders.
- •Patients on long term oxygen therapy (LTOT).
- •Patients with respiratory neuromuscular weaknesses or chest wall deformities.
- •End-organ failure and malignancies
- •Obesity hypoventilation syndrome.
Outcomes
Primary Outcomes
change of mean pulmonary artery pressure measured by echo
Time Frame: 3 months
Secondary Outcomes
- Exercise capacity improvement measured by maximun o2 consumption(3 months)
- Exercise capacity improvement measured by six minute walking test(3 months)