A Phase 2, Open-Label, Single-Arm Study to Evaluate the Safety and Efficacy of Niraparib in Patients With Advanced, Relapsed, High-Grade Serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Have Received Three or Four Previous Chemotherapy Regimens
Overview
- Phase
- Phase 2
- Intervention
- Niraparib
- Conditions
- Ovarian Neoplasms
- Sponsor
- Tesaro, Inc.
- Enrollment
- 463
- Locations
- 1
- Primary Endpoint
- Objective Response Rate (ORR)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This is a Phase 2, open-label, single arm study to evaluate the safety and efficacy of niraparib in ovarian cancer patients who have received three or four previous chemotherapy regimens. Niraparib is an orally active PARP inhibitor. Niraparib will be administered once daily continuously during a 28-day cycle. Health-related quality of life will be measured by Eastern Cooperative Oncology Group performance status (ECOG). Safety and tolerability will be assessed by clinical review of adverse events (AEs), physical examinations, electrocardiograms (ECGs), RECIST tumor assessments and safety laboratory values.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients must agree to undergo tumor HRD testing and blood gBRCAmut status testing.
- •Patients of childbearing potential must have negative pregnancy serum test within 72 hours of being dosed
- •Patients must have histologically diagnosed high-grade (Grade 2 or 3) serous epithelial ovarian, fallopian tube, or primary peritoneal cancer with recurrent disease and must have been previously treated with chemotherapy and experienced a response lasting at least 6 months to first-line platinum based therapy.
- •Patients Must have completed 3 or 4 previous chemotherapy regimens.
- •Patients must have completed their last chemotherapy regimen \> 4 weeks prior to treatment initiation.
- •Patients must have measurable disease according to RECIST (v.1.1).
- •Patients must have formalin-fixed, paraffin-embedded tumor samples available from the primary or recurrent cancer or agree to undergo fresh biopsy prior to study treatment initiation.
- •Patients must agree to blood samples during screening and at the end of treatment for cytogenetic analysis.
Exclusion Criteria
- •Patients must not have any known, persistent (\> 4 weeks), ≥Grade 3 hematologic toxicity during the last cancer therapy. Patients must not have any known, persistent (\>4 weeks), ≥ Grade 3 fatigue during the last cancer therapy.
- •Patients must not have received pelvic radiotherapy as treatment for primary or recurrent disease within 1 year of the first dose of study treatment.
- •Patients must not have symptomatic uncontrolled brain or leptomeningeal metastases.
- •Patients must not be considered a poor medical risk due to a serious, uncontrolled medical disorder, nonmalignant systemic disease or active, uncontrolled infection.
- •Patients must not have received a transfusion (platelets or red blood cells) within 4 weeks of the first dose of study treatment.
- •Patients must not have known history or current diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
Arms & Interventions
Niraparib
Intervention: Niraparib
Outcomes
Primary Outcomes
Objective Response Rate (ORR)
Time Frame: Up to 3 years
The ORR was defined as the percentage of participants achieving complete response (CR) or partial response (PR) as assessed by the Investigator per Response Evaluation Criteria in Solid Tumors (RECIST) (version1.1), where CR=Disappearance of all target lesions. Any pathological lymph nodes must be \<10 millimeters (mm) in the short axis, PR=At least a 30 percent (%) decrease in the sum of the diameters of target lesions, taking as a reference, the Baseline sum of the diameters. Primary Analysis Population comprised of participants who received 3 or 4 prior lines of therapy (LOT), had homologous recombination deficiency positive (HRDpos) tumors, had platinum-sensitive disease, and were poly(adenosine 5'-diphosphate \[ADP\]-ribose) polymerase inhibitors (PARPi) naïve.
Secondary Outcomes
- Duration of Response (DoR)(Up to 3 years)
- ORR by HRD Status and Breast Cancer Gene (BRCA) Status(Up to 3 years)
- Disease Control Rate (DCR)(Up to 3 years)
- Progression Free Survival(Up to 3 years)
- Overall Survival(Up to 3 years)
- Time to First Subsequent Therapy (TFST)(Up to 3 years)