Epidural Analgesia vs Adductor Canal Block in Bilateral TKA

Not Applicable

Completed

• Conditions: Osteo Arthritis Knee
• Interventions: Procedure: Continuous epidural block; Procedure: Bilateral single-shot bilateral adductor canal blocks

• Registration Number: NCT03205540
• Lead Sponsor: Mahidol University

Brief Summary

This study evaluates postoperative analgesic efficacy within 48 hours between epidural analgesia and single-shot bilateral adductor canal blocks in bilateral total knee arthroplasty. Half of participants will be received continuous epidural analgesia, while other half of participants will be received single-shot bilateral adductor canal blocks.

Detailed Description

Continuous epidural analgesia is effective postoperative pain control but it has some limitations in patients with hypotension, concurrent anticoagulants, technical difficulty, urinary retention.

Adductor canal block is less invasive than continuous epidural analgesia. It provides effective analgesia for total knee arthroplasty and preserves quadriceps muscle strength.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-06-29
• Study First Submitted QC: 2017-06-29
• Study First Posted: 2017-07-02
• Study Start: 2017-08-01
• Primary Completion: 2021-01-30
• Status Verified: 2021-05
• Study Completion: 2021-05-01
• Last Update Submitted: 2021-05-25
• Last Update Posted: 2021-05-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Aged more than 18 years old undergoing bilateral total knee arthroplasty
• American Society of Anesthesiologists physical status classification 1-3

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Exclusion Criteria

• Participants deny to enroll the study
• Allergy to bupivacaine
• Weight less than 50 kilograms
• Hepatic disease
• Contraincation for neuraxial block or adductor canal block
• Uncontrolled cardiovascular disease
• Creatinine clearance less than 50 ml/min

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Epidural analgesia	Continuous epidural block	Lumbar continuous epidural block
Bilateral ACB	Bilateral single-shot bilateral adductor canal blocks	Ultrasound-guided bilateral adductor canal blocks

Primary Outcome Measures

Name	Time	Method
pain scores at rests	48 hours postoperatively	numerical rating scales

Secondary Outcome Measures

Name	Time	Method
morphine consumptions	48 hours postoperatively	total miligrams of morphine use in each arm
side effects of interventions	48 hours postoperatively	nausea vomiting hypotension
pain scores on movement	48 hours postoperatively	numerical rating scales

Trial Locations

Locations (1)

Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand