A Multinational, Multicenter, Open-label, Randomized Controlled Trial to Investigate the Effectiveness of TENofovir Alafenamide in Reducing Clinical Events in Chronic Hepatitis B Patients beyond Treatment IndicaTIONs by Current Guidelines
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0003429
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 780
1. Patient must have the ability to understand and sign a written informed consent form; consent must be obtained prior to initiation of study procedures
2. Male or female, 40 to 80 years of age
3. Positive for HBsAg or HBV DNA for at least 6 months or more
4. HBeAg positive or negative
5. No evidence of liver cirrhosis (platelet count =100,000/mm3)
6. serum HBV DNA = 4 log10 IU/mL and = 8 log10 IU/mL
7. Serum ALT level <70 if male, <50 if female
8. Estimated creatinine clearance = 30 ml/min based on serum creatinine as measured at the screening evaluation
9. Patient is willing and able to comply with all study requirements
1. Co-infection with HCV, HDV, HIV (Confirmed by nucleic acid tests)
2. Abusing alcohol (more than 60 g/day) or illicit drugs
3. Patients with history of hepatic decompensation (e.g., ascites, encephalopathy or variceal hemorrhage)
4-1) Evidence of cirrhosis, including any of follows:
- Platelet count <100,000/mm3
- Esophagogastric varices on endoscopy
- Evidence of clinically significant portal hypertension
- Fibroscan = 12.0 kPa (If the test was done in 6 months before the time of screening.) and confirmed to have liver cirrhosis by an investigator
4-2) 40=ALT levels<70 IU/L (males) or 40= ALT levels<50 IU/L (females) with evidence of significant fibrosis(F2; =7.2 kPa) as measured by either liver biopsy, Fibroscan or MR elastograpy performed within 3 months.
5. Received interferon or other immunomodulatory treatment for HBV infection in the 12 months before screening for this study
6. Medical condition that requires concurrent use of systemic corticosteroid or other immunosuppressive agents
7. Received solid organ or bone marrow transplant
8. Known hypersensitivity to study drugs, metabolites, or formulation excipients
9. Any other clinical condition or prior therapy that, in the opinion of the Investigator, would make the patient unsuitable for the study or unable to comply with dosing requirements
10. Use of investigational agents within 6 months of screening, unless allowed by the Sponsor or Investigator
11. Any malignant tumor in the preceding five years. However, a history of treated malignancy (other than HCC) is allowable if the patient’s malignancy has been in complete remission, off chemotherapy and without additional surgical intervention, during the preceding three years
12. Participating in other clinical trials to administer medication. However, it is possible to participate if it is not an antiviral agent or immunosuppressant related clinical trial.
13. Pregnant or breastfeeding or willing to be pregnant
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cumulative rate of patients with clinical events (death, liver transplantation, liver decompensation[Child-Pugh score 7], portal hypertensive complications, and HCC)
- Secondary Outcome Measures
Name Time Method