Vascular Dysfunction in Offspring of Assisted Reproduction Technologies

• Conditions: Infertility
• Interventions: Diagnostic Test: Transthoracic echocardiography

• Registration Number: NCT00837642
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

The prevalence of infertility has been estimated at 9% worldwide. The steadily increasing use of assisted reproductive technologies (ART) has allowed millions of infertile couples to have children. These children make up for 1 to 4% of the population in developed countries. ART involves the manipulation of early embryos at a time when they may be particularly vulnerable to external disturbances. In line with this concept, studies in mice suggest that ART alters the activity of enzymes involved in the regulation of metabolic and cardiovascular homeostasis. Alternatively, infertility itself or the drugs used to stimulate ovulation may have adverse effects on the outcome of the offspring. The safety of ART for long-term health is, therefore, of utmost importance. Among the potential long-term consequences of ART, cardiovascular disease may represent an important candidate, but there is no information.

Investigators show that, children born after in vitro fertilization (IVF) present systemic and pulmonary vascular dysfunction at high-altitude when compared to age- and sex-matched control subjects. A 5 years follow-up study shows that premature vascular aegieng persist and evolve to arterial hypertension. Arterial hypertension may induce cardiac dysfunction.

Therefore, the major goal of this proposal is to assess cardiac function in apparently healthy participants born after ART.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2009-02-04
• Study First Submitted QC: 2009-02-04
• Study First Posted: 2009-02-05
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-19
• Last Update Posted: 2020-02-20
• Primary Completion: 2020-12
• Study Completion: 2021-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Offspring of ART
• Healthy
• Born at term

Exclusion Criteria

• Cardio-pulmonary malformations
• Neuro-muscular malformations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ART (Assited reproductive technologies)	Transthoracic echocardiography	In participants born after IVF will be performed a transthoracic echocardiography
Control	Transthoracic echocardiography	In participants naturally conceived will be performed a transthoracic echocardiography

Primary Outcome Measures

Name	Time	Method
Cardiac function	1 year	Ejection fraction \[%\]

Secondary Outcome Measures

Name	Time	Method
Left ventricular musce mass	1 year	Left ventricular muscle mass \[g/m2\]

Trial Locations

Locations (1)

University Hospital; 🇨🇭 Bern, BE, Switzerland