Hyperglycemic Response to Steroid Administration After Noncardiac Surgery in Patients With and Without Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- glucose concentration
研究概览
简要总结
The hyperglycemic response to surgery and the added effect of low-dose steroids (dexamethasone 4 to 8mg), and whether these differ in diabetics and nondiabetics remain unclear. Therefore, we prospectively evaluate the intraoperative and postoperative serum glucose concentrations in diabetics and nondiabetics that received intravenous steroid administration. This multicentre study include > 250 patients.Primary endpoiunt was glucose concentration at H6 after surgery. Secondary endpoints were glucose concentration at H12 and at H24 and effect of anesthesia (regional anesthesia)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •elective surgery under anesthesia
排除标准
- •emergency
- •insulin therapy
- •cardiac surgery
- •hyperglycemia> 2g/L
研究组 & 干预措施
diabetes
Patient with non insulin diabetes
干预措施: Steroid Drug (Drug)
control
Patient without diabete
干预措施: Steroid Drug (Drug)
结局指标
主要结局
glucose concentration
时间窗: 6-8 hour
次要结局
- glucose concentration(12 hour)
- glucose concentraion(24 hour)
研究者
Philippe Cuvillon
PhD
Centre Hospitalier Universitaire de Nīmes