CTRI/2022/11/047033尚未招募2 期
Efficacy of weekly paclitaxel with fixed dose of oral cyclophosphamide as metronomic chemotherapy in recurrent /refractory gastric carcinoma â?? phase 2 study
JIPMER PONDICHERRY0 个研究点目标入组 0 人开始时间: 待定最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1Confirmed histological diagnosis of gastric carcinoma.
- •2Age 18 years to 70 years at time of enrollment
- •3Recurrent and refractory gastric carcinoma
- •4ECOG performance status 0 to 2
- •5Documented disease progression as evidenced by clinical, radiological or both
- •6 Normal echocardiogram
- •7Negative serum pregnancy test in women of child bearing age
排除标准
- •1Active bleeding
- •2History of severe hypersensitivity reaction to paclitaxel.
- •3Patients having > grade 2 neuropathy
- •4Patient planned for immunotherapy and anti-her-2 therapies.
- •5Gastric outlet obstruction(GOO) without appropriate feeding procedure.
- •6 Biological parameters
- •1.Absolute granulocytes <= 1500/mm3
- •2.Platelets <= 75,000/mm3
- •3.Hemoglobin <= 8 g/L
- •4.Serum albumin level <= 28 g/L
- •5.Bilirubin > 1.5 and AST/ALT >= 3 ULN or >= 5 ULN in case of liver metastasis
- •6.Sr. Creatinine > 2.0 or creatinine clearance of < 50ml/min
研究者
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