Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 160
- Locations
- 1
- Primary Endpoint
- Determination of DLPFC beta power a biomarker of DBS associated cognitive impairment in the acute stimulation setting
- Status
- Active, Not Recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Investigators
Sarah Bick
Assistant Professor of Neurosurgery
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)
- •Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
- •Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
- •Age at least 18
- •Able to participate in intraoperative testing
- •English speaking
Exclusion Criteria
- •Age less than 18
- •Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
Outcomes
Primary Outcomes
Determination of DLPFC beta power a biomarker of DBS associated cognitive impairment in the acute stimulation setting
Time Frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Working memory tasked will be conducted during surgery, and local field potentials (LFPs) will be recorded from the DLPFC both at rest and during task execution, under two conditions: with and without stimulation.
Determination of STN local field potential biomarkers of DBS mediated cognitive impairment following chronic stimulation
Time Frame: 1 hour
Local field potentials will be recorded from subthalamic nucleus or globus pallidus internus in patients with an existing DBS system with implantable pulse generator capable of recording local field potentials. Recordings will be performed at rest and during a working memory task, with DBS on and off.