Cardiovascular Risk Early Screening and Warning in Harbin : A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Major adverse cardiovascular event (MACE)
研究概览
简要总结
The aim of this prospective cohort study is to collect the multi-omics profile of cardiovascular disease (CVD) high-risk individuals in Harbin, and to discover novel biomarker signatures of major adverse cardiovascular events (MACE) during a minimum 2-year follow-up period.
详细描述
This is a single-center, observational, prospective cohort study. The primary endpoint is the incidence of MACE. Participants must meet at least two of the following criteria: hypertension, hyperglycemia, hyperlipidemia, or obesity. Baseline data and biological samples will be collected at enrollment, with clinical outcomes monitored for a minimum of two years. The study aims to enroll 10,000 participants aged 45 years and older from Harbin city, located in northeastern China.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1.Residents of Harbin city, regardless of gender.
- •2.Meets at least two of the following conditions: diabetes, hypertension, hyperlipidemia, or obesity.
- •3.No history of cardiovascular or cerebrovascular diseases.
- •4.Willing to participate in the study and sign the informed consent form
排除标准
- •1.History of antibiotic or probiotic treatment within the past month.
- •Pregnant women.
- •History of autoimmune diseases or malignant tumors; severe heart, liver, or kidney dysfunction; or a history of severe cardiovascular or cerebrovascular diseases.
- •Any unstable condition or situation that may jeopardize patient safety or compliance.
- •Patients unable to provide informed consent due to physical reasons or unwilling to participate.
结局指标
主要结局
Major adverse cardiovascular event (MACE)
时间窗: 2 years
A major adverse cardiovascular event (MACE) of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke
次要结局
- Cardiovascular death(2 years)
- All-cause death(2 years)
- Myocardial infarction(2 years)
- Stroke(2 years)
研究者
Yu Bo
Director, Cardiology Department, the 2nd Affiliated Hospital of Harbin Medical University
Harbin Medical University