A Comparison Between Conventional Surgery and Piezosurgery

Not Applicable

Completed

• Conditions: Third Molars Extraction
• Interventions: Device: Piezosurgery

• Registration Number: NCT02495207
• Lead Sponsor: Damascus University

Brief Summary

Evaluation of the effect of conventional and piezo-surgery on the secretion of Heat Shock Protein (HSP70) and on the vial bone cells at the peripheral bone cut sides after the removal of impacted mandibular third molars on both sides of the jaw.

Detailed Description

The study is about measuring the amount of HSP70 using Elisa kit for detecting HSP70 and mason trichrome for histological findings in which the study samples are patients who have bilateral impacted mandibular third molar to be extracted with bone removal. First we collect bone sample for mason trichrome with either method then we collect the second samples after removing most of the bones cover the impacted third molar for checking HSP70 levels. Then the bone samples are treated using a special protocol to eliminate the protein from bone samples for the Elisa analysis. The other bone samples are going to be studied under the microscope.

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2015-06-19
• Study First Submitted QC: 2015-07-09
• Study First Posted: 2015-07-13
• Primary Completion: 2016-03-14
• Study Completion: 2017-04-14
• Status Verified: 2017-07
• Last Update Submitted: 2017-07-26
• Last Update Posted: 2017-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• bilateral identical impacted third molar that need at least 3 mm of bone removal

Exclusion Criteria

• Pregnancy
• Smokers
• Infectious diseases
• Infections around third molars (i.e. pericoronitis).
• Alcoholic patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Piezosurgery	Piezosurgery	Patients here will undergo a piezosurgery to extract their third molars on both sides.

Primary Outcome Measures

Name	Time	Method
Levels of Heat Shock Protein 70	Five minutes before third molar removal with the last removed layer of bone	This will be measured using ELISA methodology

Secondary Outcome Measures

Name	Time	Method
Percentage of viable bone cells	This variable will be measured from the specimens taken within the first 15 minutes of bone cutting to remove third molars	Percentage of viable bone cells will be calculated based on the counts of viable bone cells observed under the microscope.

Trial Locations

Locations (1)

Department of Oral and Maxillofacial Surgery, University of Damascus Dental School; 🇸🇾 Damascus, Damscus, Syrian Arab Republic