Evaluation of the Free α-hemoglobin Pool in the Red Blood Cells : Prognostic Marker and Severity Index in Thalassemic Syndromes
Not Applicable
Completed
- Conditions
- Thalassemic Syndromes
- Registration Number
- NCT02855957
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Our project aims to assess and validate an innovative prognostic and diagnostic test in order to i) define a severity index of the β-thalassemia according to the free α-Hb pool for a better management of the patient; ii) differentiate the α-thalassemia and β-thalassemia and iii) follow the evolution of this pool in response to treatment of patients. In the future, this prognostic test based on the measurement of free α-Hb pool may be suitable for routine laboratory practice. To carry out this project, cohort of 85 thalassemic patients and a group of 50 healthy volunteers have been recruited.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 135
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Correlation between the pool of free α-Hb and genotype α and β -globin of the patient and if necessary with the genotype AHSP gene Day 1
- Secondary Outcome Measures
Name Time Method Correlation between the pool of free α-Hb and Mean Cell Volume Day 1 Correlation between the pool of free α-Hb and percent of reticulocytes Day 1 Correlation between the pool of free α-Hb and Hb value Day 1 Correlation between the pool of free α-Hb and fetal Hb Day 1 Correlation between the pool of free α-Hb and erythrocyte enzymes Day 1 Correlation between the pool of free α-Hb and Mean Corpuscular Hb Day 1
Trial Locations
- Locations (1)
Henri Mondor Hospital
🇫🇷Creteil, France
Henri Mondor Hospital🇫🇷Creteil, France