To compare efficacy of kokilakshadi kashayam & kaishore gugguluin management of vatarakra wsr to gout

Phase 2/3

Not yet recruiting

Conditions: Hyperuricemia without signs of inflammatory arthritis and tophaceous disease. Ayurveda Condition: VATARAKTAM,

Lead Sponsor: Shri krishna government ayurvedic college and hospital sec 8 umri road kurukshetra

Brief Summary: Vatarakta (Gout) is a metabolic disorder, caused by abrupt change in the lifestyle, change in dietary habits. The incidence of gout varies in population from 0.2 to 3.5 per 1000, with an overall prevalence of 2-26 per 1000. Gout is found to have increased prevalence in recent years. It is rare in children and premenopausal females. The peak age of onset in males is between 40 and 50 years. In modern science, NSAIDs (Non-Steroid Anti Inflammatory Drugs), Xanthine Oxidase Inhibitors (Allopurinol, Febuxostat), Colchicines, Probenecids & corticosteroids are the most widely used medicine for the treatment of Gout, but these have many side effects when used for a longer duration. Keeping in view of the above limitations and side effects, this study has been chosen to fill the gap of providing a safe and effective line of treatment as Ayurveda provides multiple formulations for VataRakta. So, an effort is made to see whether Kokilakshadi Kashayam or Kaishore Guggulu is effective in the management of VataRakta and also comparing their efficacy.In this study, we will have two groups of 30 patients each. these groups will be treated with Kokilakshadi Kashayam and Kaishore Guggulu respectively. We will have a follow up on 0th, 15th and 30th day (During treatment) and on 60th day (post treatment). The changes will be analyze on the basis of subjective and objective parameters in both groups, Then the result will be analyzed by using appropriate statistical method.

Recruitment & Eligibility

Inclusion Criteria

1.Patients between the age group of 19-60 years of either sex presented with clinical features of VataRakta/ Gout.
2.Diagnosed and confirmed the case of VataRakta (Gout).
3.Patients have serum uric acid levels of more than 6mg/dl in females & more than 7mg/dl in males with or without any associated features like joint pain and inflammation.

Exclusion Criteria

1.Patients below 19 years and above 60 years will be excluded 2.Patients suffering from other forms of Arthritis like Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Infective arthritis, etc.
3.Pregnant and lactating mother.
4.Subject showing the uric acid level above 9mg/dl.
5.Patients with evidence of malignancy & on chemotherapy drugs.
6.Patients having any disorders like Diabetes mellitus, Cardiac disease, CRF, ARF, etc.

Primary Outcome Measures

Name	Time	Method
The efficacy of Kokilakshadi Kashayam and Kaishore Guggulu will be noted in respective groups as per changes in subjective criteria on the 15th 30th day and 60th-day post-treatment and repeat lab investigation (CBC, ESR, CRP (Quantitative), Serum UA, Blood Urea, Serum Creatinine, RA Factor) will be done post-treatment.	30 days of treatment with follow up on 15th, 30th and 60th day

Secondary Outcome Measures

Name	Time	Method
1) To Compare efficacy of Kokilakshadi Kashaya & Kaishore Guggulu after complete treatment & follow up of both groups.	2.Evalution of adverse effect of both drug will be done on each patient during & post treatment.

Locations (1): Shri Krishna Government Ayurvedic hospital
🇮🇳
Kurukshetra, HARYANA, India
Shri Krishna Government Ayurvedic hospital
🇮🇳Kurukshetra, HARYANA, India
Anjali Jamra
Principal investigator
08234040010
pinkyjamra27@gmail.com