Treatment of CNS germinoma with chemotherapy and radiotherapy
Not Applicable
Active, not recruiting
- Conditions
- Neoplasms
- Registration Number
- KCT0005442
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
1) Pathologically proven CNS germinoma
2) Age: 3-30 years
3) Normal plasma and CSF aFP
4) Plasma and CSF b-hCG < 200 mIU/ml
5) Patients with informed consent
Exclusion Criteria
1) Patients with organ dysfunction as follows
- Serum Cr > 1.5 x ULN or creatinine clearance = 30 mL/min
- Cardiac ejection fraction <40% or severe arrhythmia or conduction disorder
2) Other sever mediacal illness which makes scheduled treatment impossible
3) Pregnant or nursing women
4) Patients with a past history of severe hypersensitivity to clinical trial drugs
5) Patients who are currently using pentostatin
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of event free survival
- Secondary Outcome Measures
Name Time Method Rate of late adverse effects