Echocardiographic Assessment of Ventricular Strain During a Healthy Pregnancy in the First, Second, and Third Trimester.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Echocardiography
- Sponsor
- Miguel Ayala León
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- A mitr
- Last Updated
- 5 years ago
Overview
Brief Summary
Pregnancy is a physiological situation that produces transient preload and afterload changes. The heart is subjected to reversible morphological remodelings and hemodynamic and functional adaptations. The characterization and understanding of maternal cardiac function during normal pregnancy by echocardiography 2D is of clinical importance for the opportune recognition of cardiac pathology.
This study aims to investigate pregnancy-induced changes in ventricular strain in healthy pregnant women by echocardiography.
Investigators
Miguel Ayala León
cardiovascular critical care unit director
Hospital Beneficencia Espanola de Puebla
Eligibility Criteria
Inclusion Criteria
- •Age ≥18 years and \< 35
- •Patients who coursing the first trimester of pregnancy
- •No history or symptoms of cardiovascular or lung disease
- •No ongoing or previous cardio or vasoactive treatment
- •Normal ECG
- •Normal physical examination
- •Able to give informed consent
Exclusion Criteria
- •Poor acoustic window
- •Obesity in the first trimester (body mass index \[BMI\], ≥30 kg/m2)
- •Inability to provide consent.
- •Tricuspid regurgitation more than mild
- •Collagen disease
- •Professional sports activity
- •Twin pregnancy
- •Hyperthyroidism
Outcomes
Primary Outcomes
A mitr
Time Frame: 3 minutes
Mitral A wave (cm/s)
Em
Time Frame: 3 minutes
E-wave at mitral annulus (cm/s)
Left atrium volume index (LA volume index)
Time Frame: 3 minutes
Left atrium volume index (mL/m2)
E/A tric
Time Frame: 3 minutes
Tricuspid E wave/Tricuspid A wave
Left ventricular telediastolic diameter (LVTDd)
Time Frame: 3 minutes
Left ventricular telediastolic diameter (mm)
Left ventricular telesystolic diamete (LVTSd)
Time Frame: 3 minutes
Left ventricular telesystolic diameter (mm)
Interventricular septum (IVS)
Time Frame: 3 minutes
Diameter of Interventricular septum (mm)
Left ventricular posterior wall (LVPW)
Time Frame: 3 minutes
Left ventricle posterior wall (mm)
Ejection fraction (EF)
Time Frame: 3 minutes
Ejection fraction (%)
Right atrium area (RA area)
Time Frame: 3 minutes
Right atrium area (cm2)
Right ventricular M
Time Frame: 3 minutes
Right ventricle mid cavity dimension (mm)
Right ventricular L
Time Frame: 3 minutes
Right ventricle longitudinal dimension (mm)
Right ventricle outflow tract dimension at the proximal subvalvular level (RVOT p)
Time Frame: 3 minutes
Right ventricle outflow tract dimension at the proximal subvalvular level (mm)
Right ventricle outflow tract dimension at the distal or pulmonic valve level (RVOT d)
Time Frame: 3 minutes
Right ventricle outflow tract dimension at the distal or pulmonic valve level (mm)
Tricuspid annular plane systolic excursion (TAPSE)
Time Frame: 3 minutes
Tricuspid annular plane systolic excursion (mm)
Inferior cava vein (ICV)
Time Frame: 3 minutes
Inferior cava vein (mm)
Sm
Time Frame: 3 minutes
S-wave at mitral anulus (cm/s)
Em/Am
Time Frame: 3 minutes
E-wave at mitral annulus/ A-wave at mitral annulus
E tric
Time Frame: 3 minutes
Tricuspid E wave (cm/s)
Right ventricle B
Time Frame: 3 minutes
Right ventricle basal dimension (mm)
Right ventricle free wall (RV free wall)
Time Frame: 3 minutes
Right ventricle free wall (mm)
E mitr
Time Frame: 3 minutes
Mitral E wave (cm/s)
Am
Time Frame: 3 minutes
A-wave at mitral annulus (cm/s)
E/Em
Time Frame: 3 minutes
E wave/ E-wave at the mitral annulus
Et
Time Frame: 3 minutes
E-wave at tricuspid anulus(cm/s)
Strain right ventricle (Strain RV)
Time Frame: 3 minutes
Strain right ventricle
E/A mitr
Time Frame: 3 minutes
Mitral E wave / Mitral A wave
A tric (cm/s)
Time Frame: 3 minutes
Tricuspid A wave (cm/s)
St
Time Frame: 3 minutes
S-wave at tricuspid anulus(cm/s)
Et/At
Time Frame: 3 minutes
E-wave at tricuspid anulus /A-wave at tricuspid anulus
At
Time Frame: 3 minutes
A-wave at tricuspid anulus (cm/s)
Mean pulmonary artery pressure (mPAP)
Time Frame: 3 minutes
Mean pulmonary artery pressure (mmHg)
Systolic pulmonary artery pressure (sPAP)
Time Frame: 3 minutes
Systolic pulmonary artery pressure (mmHg)
Cardiac output (CO)
Time Frame: 3 minutes
Cardiac output (L/min)
Strain left ventricle (Strain LV)
Time Frame: 3 minutes
Strain left ventricle
Stroke volume (SV)
Time Frame: 3 minutes
Stroke volume (mL)