Echocardiographic Assessment of Ventricular Strain During a Healthy Pregnancy in the First, Second, and Third Trimester.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- A mitr
研究概览
简要总结
Pregnancy is a physiological situation that produces transient preload and afterload changes. The heart is subjected to reversible morphological remodelings and hemodynamic and functional adaptations. The characterization and understanding of maternal cardiac function during normal pregnancy by echocardiography 2D is of clinical importance for the opportune recognition of cardiac pathology.
This study aims to investigate pregnancy-induced changes in ventricular strain in healthy pregnant women by echocardiography.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years and < 35
- •Patients who coursing the first trimester of pregnancy
- •No history or symptoms of cardiovascular or lung disease
- •No ongoing or previous cardio or vasoactive treatment
- •Normal ECG
- •Normal physical examination
- •Able to give informed consent
排除标准
- •Poor acoustic window
- •Obesity in the first trimester (body mass index [BMI], ≥30 kg/m2)
- •Inability to provide consent.
- •Tricuspid regurgitation more than mild
- •Collagen disease
- •Professional sports activity
- •Twin pregnancy
- •Hyperthyroidism
结局指标
主要结局
A mitr
时间窗: 3 minutes
Mitral A wave (cm/s)
Em
时间窗: 3 minutes
E-wave at mitral annulus (cm/s)
Left atrium volume index (LA volume index)
时间窗: 3 minutes
Left atrium volume index (mL/m2)
E/A tric
时间窗: 3 minutes
Tricuspid E wave/Tricuspid A wave
Left ventricular telediastolic diameter (LVTDd)
时间窗: 3 minutes
Left ventricular telediastolic diameter (mm)
Left ventricular telesystolic diamete (LVTSd)
时间窗: 3 minutes
Left ventricular telesystolic diameter (mm)
Interventricular septum (IVS)
时间窗: 3 minutes
Diameter of Interventricular septum (mm)
Left ventricular posterior wall (LVPW)
时间窗: 3 minutes
Left ventricle posterior wall (mm)
Ejection fraction (EF)
时间窗: 3 minutes
Ejection fraction (%)
Right atrium area (RA area)
时间窗: 3 minutes
Right atrium area (cm2)
Right ventricular M
时间窗: 3 minutes
Right ventricle mid cavity dimension (mm)
Right ventricular L
时间窗: 3 minutes
Right ventricle longitudinal dimension (mm)
Right ventricle outflow tract dimension at the proximal subvalvular level (RVOT p)
时间窗: 3 minutes
Right ventricle outflow tract dimension at the proximal subvalvular level (mm)
Right ventricle outflow tract dimension at the distal or pulmonic valve level (RVOT d)
时间窗: 3 minutes
Right ventricle outflow tract dimension at the distal or pulmonic valve level (mm)
Tricuspid annular plane systolic excursion (TAPSE)
时间窗: 3 minutes
Tricuspid annular plane systolic excursion (mm)
Inferior cava vein (ICV)
时间窗: 3 minutes
Inferior cava vein (mm)
Sm
时间窗: 3 minutes
S-wave at mitral anulus (cm/s)
Em/Am
时间窗: 3 minutes
E-wave at mitral annulus/ A-wave at mitral annulus
E tric
时间窗: 3 minutes
Tricuspid E wave (cm/s)
Right ventricle B
时间窗: 3 minutes
Right ventricle basal dimension (mm)
Right ventricle free wall (RV free wall)
时间窗: 3 minutes
Right ventricle free wall (mm)
E mitr
时间窗: 3 minutes
Mitral E wave (cm/s)
Am
时间窗: 3 minutes
A-wave at mitral annulus (cm/s)
E/Em
时间窗: 3 minutes
E wave/ E-wave at the mitral annulus
Et
时间窗: 3 minutes
E-wave at tricuspid anulus(cm/s)
Strain right ventricle (Strain RV)
时间窗: 3 minutes
Strain right ventricle
E/A mitr
时间窗: 3 minutes
Mitral E wave / Mitral A wave
A tric (cm/s)
时间窗: 3 minutes
Tricuspid A wave (cm/s)
St
时间窗: 3 minutes
S-wave at tricuspid anulus(cm/s)
Et/At
时间窗: 3 minutes
E-wave at tricuspid anulus /A-wave at tricuspid anulus
At
时间窗: 3 minutes
A-wave at tricuspid anulus (cm/s)
Mean pulmonary artery pressure (mPAP)
时间窗: 3 minutes
Mean pulmonary artery pressure (mmHg)
Systolic pulmonary artery pressure (sPAP)
时间窗: 3 minutes
Systolic pulmonary artery pressure (mmHg)
Cardiac output (CO)
时间窗: 3 minutes
Cardiac output (L/min)
Strain left ventricle (Strain LV)
时间窗: 3 minutes
Strain left ventricle
Stroke volume (SV)
时间窗: 3 minutes
Stroke volume (mL)
次要结局
未报告次要终点
研究者
Miguel Ayala León
cardiovascular critical care unit director
Hospital Beneficencia Espanola de Puebla