Effects of Music Beat on Motor Function in Individuals At Risk for Psychotic Onset and Schizophrenia Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
研究概览
简要总结
The purpose of this project is to investigate whether a 3-week training program involving music beat (serving as a type of rhythmic auditory stimulation) reduces the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients. It is hypothesized that the program is effective in reducing the severity of bradykinesia and dyskinesia in at-risk individuals and schizophrenia patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 13 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For at-risk participants:
- •Inclusion criteria:
- •A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);
- •an age of 13 years or above;
- •score > 60 in The Chinese version of Edinburgh Handedness Inventory (CH-EBI) to ensure right handedness; and
- •score ≥ 22 in Montreal Cognitive Assessment Hong Kong Version (HK-MoCA) to ensure no serious cognitive deficits so that they can understand instructions.
排除标准
- •psychiatric diagnosis by self-report;
- •cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
- •taking psychiatric medications;
- •substance abuse; and
- •being pregnant.
- •For schizophrenia participants:
- •Inclusion criteria:
- •a diagnosis of schizophrenia without other psychiatric diseases;
- •the age ≥ 18 years;
- •score > 60 in CH-EBI to ensure right handedness; and
- •score ≥ 22 in HK-MoCA to ensure no serious cognitive deficits so that they can understand instructions.
- •Exclusion criteria:
- •cardiovascular, neurological, muscular or orthopedic diseases that may affect hand movements;
- •substance abuse; and
- •being pregnant.
研究组 & 干预措施
at risk- RAS
At-risk individuals in the experimental group will undergo upper-limb movement training with the aid of music beat serving as a type of rhythmic auditory stimulation (RAS).
干预措施: Rhythmic auditory stimulation (RAS) (Behavioral)
at risk- no RAS
At-risk individuals in the control group will receive upper-limb training without the aid of RAS.
干预措施: no RAS (Behavioral)
schizophrenia- RAS
Schizophrenia patients in the experimental group will undergo upper-limb movement training with the aid of RAS.
干预措施: Rhythmic auditory stimulation (RAS) (Behavioral)
schizophrenia- no RAS
Schizophrenia patients in the control group will receive upper-limb training without the aid of RAS.
干预措施: no RAS (Behavioral)
结局指标
主要结局
Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
时间窗: Within one week right after the last session of the intervention
normalized movement time (representing severity of bradykinesia). Unit: second/mm
Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
时间窗: Within one week right before the 1st session of the intervention
normalized movement time (representing severity of bradykinesia). Unit: second/mm
次要结局
未报告次要终点
研究者
Dr WANG Shumei
Assistant Professor
The Hong Kong Polytechnic University