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Clinical Trials/NCT04104568
NCT04104568
Suspended
Not Applicable

Effectiveness of an Online Training and Support Program (iSupport Portuguese Version) to Reduce Burden, Depression and Anxiety and to Improve Quality of Life, Positive Aspects of Caregiving and Self-efficacy in Informal Dementia Caregivers

Universidade do Porto1 site in 1 country184 target enrollmentMarch 5, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Caregiver Subjective Burden
Sponsor
Universidade do Porto
Enrollment
184
Locations
1
Primary Endpoint
Change from baseline in subjective burden using the Zarit Burden Interview (ZBI)
Status
Suspended
Last Updated
3 years ago

Overview

Brief Summary

Informal caregivers of people with dementia are at greater risk of developing physical and mental health problems when compared to the general population and to informal caregivers of people with other chronic diseases. Internet-based interventions have been explored in its potential to minimize the negative effects of caring, accounting for their ubiquitous nature, convenient delivery, potential scalability and presumed (cost)effectiveness. iSupport is a self-help online program developed by the World Health Organization to provide education, skills training and support to informal caregivers of people with dementia. This intervention study aims to determine the effectiveness of a Portuguese culturally adapted version of iSupport to decrease caregiver burden, symptoms of depression and anxiety, and to improve quality of life, positive aspects of caregiving and general self-efficacy. The study has two arms: access to "iSupport" for three months or access to an education-only e-book. iSupport is grounded in problem-solving and cognitive behavioral therapy techniques and it consists of 23 lessons organized around 5 modules: 'Introduction to dementia'; 'Being a carer', 'Caring for me', 'Providing everyday care', and 'Dealing with behaviour changes'.

One hundred and eighty four participants will be recruited by referral from national Alzheimer's associations. Participants will be included if they match the following criteria: being 18 years or older and provide e-consent; being a self-reported non-paid caregiver for at least 6 months; caring for a person with a formal diagnosis of Alzheimer's disease; being skilled to use internet; and experience a clinically relevant level of burden or depression or anxiety symptoms. Data is collected online, resorting to self-administered instruments, at baseline, 3 and 6 months after baseline. A two-sided alternative hypothesis was assumed for this study: Mean caregiver burden at 3 months after baseline is different in informal caregivers of people with dementia assigned to the iSupport program as in those assigned to a minimal education-only intervention. Findings from this intervention study will offer evidence to support an informed decision making on scaling up iSupport as a new intervention program with minimal costs aimed at minimizing the psychological distress of informal caregivers of people with dementia in Portugal and elsewhere.

Registry
clinicaltrials.gov
Start Date
March 5, 2020
End Date
December 2023
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Portuguese adults (≥18 years) (as self-reported and reported by professionals in the referral process);
  • Giving consent to participate (Electronic Informed Consent);
  • Providing non-paid care for at least 6 months at the time of the recruitment (as self-reported and reported by professionals in the referral process);
  • Caring for a person holding a formal diagnosis of dementia (as reported by professionals in the referral process);
  • Be skilled to use the internet (as self-reported and reported by professionals in the referral process);
  • Experiencing either a clinically relevant level of subjective burden, as determined by a total score ≥ 21 on the Zarit Burden Interview or depression or anxiety symptoms, determined by a score ≥ 8 in at least one of the subscales of the Hospital Anxiety and Depression Scale.

Exclusion Criteria

  • Unable to comprehend written Portuguese (as reported by professionals in the referral process);
  • Not having access to a device with internet connection at least twice a week (as self-reported and reported by professionals in the referral process);
  • Declaring to care for a person in institutional care (e.g. nursing home or continued care unit) (as self-reported and reported by professionals in the referral process).

Outcomes

Primary Outcomes

Change from baseline in subjective burden using the Zarit Burden Interview (ZBI)

Time Frame: Baseline, Month 3, Month 6

Caregiver burden measured with the Zarit Burden Interview (ZBI), Portuguese validated version, total score. The instrument comprises 22 items answered on a 5-point scale, ranging from 0 (never) to 4 (almost always) except for the final question on global burden, rated from 0 (not at all) to 4 (extremely). Total score for the ZBI ranges from 0 to 88 points, with higher scores indicating greater burden. The ZBI has good internal consistency (0.89), test-retest and interrater reliability as well as construct and concurrent validity, including reports of positive correlation with depression symptoms and time devoted to care provision. Regarding the psychometric properties of ZBI in Portugal, face, content, ecological, discriminant and convergent validity were documented, along with test-retest reliability (ICC= 0.93, CI95% 0.88 - 0.96, p \< 0.001) and internal consistency (α = 0.88). The ZBI is one of the most used instruments to measure burden in intervention studies with caregivers.

Secondary Outcomes

  • Change from baseline in symptoms of depression and anxiety using the Hospital Anxiety and Depression Scale (HADS)(Baseline, Month 3, Month 6)
  • Change from baseline in quality of life using the WHOQOL-BREF(Baseline, Month 3, Month 6)
  • Change from baseline in Positive Aspects of Caregiving using the Positive Aspects of Caregiving (PAC)(Baseline, Month 3, Month 6)
  • Change from baseline in General self-efficacy using the Generalized self-efficacy scale(Baseline, Month 3, Month 6)

Study Sites (1)

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