The effects of physical activity pattern on disease progression in patients with knee osteoarthritis

Recruiting

• Conditions: early-stage knee osteoarthritis / knee arthrosis; 10028393

• Registration Number: NL-OMON51855
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 24 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 332

Inclusion Criteria

Patients (m/f) aged 45-65 years

Presence of non-traumatic knee complaints for at least three months

NICE guideline diagnosis of clinical knee OA (i.e. aged 45 or over and activity
related joint pain and either no morning joint-related stiffness or morning
stiffness that lasts no longer than 30 minutes)

Average physical activity level of the performed type of activity, which is
their primary sport activity, in the last 6 months:
o Running: >= 60 minutes running per week
o Cycling: >= 120 minutes cycling per week
o Tennis: >= 1 hour (match and/or training session) per week
o Hiking: >= 30 kilometer hiking per month

Exclusion Criteria

Other pathological conditions that could explain knee complaints like traumatic
onset knee complaints, presence of other forms of arthritis (rheumatoid
arthritis, psoriatic arthritis), pre-patellar bursitis or patellar tendinitis

Onset of knee complaints > 24 months ago

Contraindications for MRI

No mobile phone or wearable device to track physical activity and unwilling to
share tracked physical activity data.

Presence of any complaints other than knee OA resulting in physical impairment
that will limit the physical activity

Unwilling to participate
No or insufficient knowledge of Dutch language
No access to e-mail

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in structural progression of knee OA between the selected physical<br /><br>activities (running, cycling, tennis, and hiking) after 24 months follow-up,<br /><br>scored using our recently introduced definitions for longitudinal evaluation of<br /><br>OA MRI features.<br /><br><br /><br>Structural progression of knee OA: scored using recently proposed definitions<br /><br>by our research group for longitudinal evaluation of OA MRI features.<br /><br>All subregional change scores (1 for progression, *1 for improvement and 0 for<br /><br>no change) will be summed over the different MRI Osteoarthritis Knee Score<br /><br>(MOAKS) subregions into an overall measure of change per feature.<br /><br>The summed change scores per feature will consequently be dichotomized into<br /><br>progression versus no progression (change score >= 1 = progression, change score<br /><br>< 1 = no progression).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Differences in clinical progression of knee OA expressed as change on<br /><br>sub-scales of KOOS and patient nominated activity pain score between the<br /><br>selected physical activities (running, cycling, tennis, and hiking) after 24<br /><br>months follow-up.<br /><br>2. Association between GPS-based individual activity profiles and increased<br /><br>risk of knee OA progression<br /><br>3. Interaction between inflammation (including inflammatory markers IL-6, CRP,<br /><br>proteomics and questionnaire data) and genetics and physical activity on the<br /><br>progression of clinical and structural knee OA<br /><br>4. Interaction between physical activity and known risk factors for knee OA, on<br /><br>the progression of knee OA</p><br>