Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Restoration of ovarian function by using autograft
研究概览
简要总结
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to collect data on the efficiency of the graft in terms of restoration of ovarian function and live births. It will also allow us to carry out the patient follow-up after ovarian tissue cryopreservation and after autograft when achieved. In cases of neoplastic malignancies, minimal residual disease detection will be performed on ovarian tissue, to avoid any risk of cancer re-seeding.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent Ovarian tissue cryopreservation
- •Premature ovarian failure
- •Patients cured of their primary disease
- •Women between 18 and 43 years of age
- •Patients who have already benefited from ovarian tissue autograft
排除标准
- •Patients under trusteeship
- •Patients placed in receivers
- •Patients under the protection of a conservator
结局指标
主要结局
Restoration of ovarian function by using autograft
时间窗: 2 years
次要结局
- Number of live births after ovarian tissue autograft(5 years)
- Number of graft recovery(5 years)
- Number of residual disease development.(5 years)
- Number of complications that could result from a surgery with anesthesia or depending on graft quality(5 years)