assessment of the effect of tranexamic acid on intraoperative blood loss in patients who undergo the surjery which the skull is opened in, for tumor excisio
Phase 2
- Conditions
- brain tumor.Other specified disorders of brain in diseases classified elsewhere
- Registration Number
- IRCT2016122631573N1
- Lead Sponsor
- Ahvaz Jundishapur University Of Medical Sciences, Ahvaz, Iran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Exclusion criteria: Patients with liver, kidney and blood disorders or with previous thrombosis disease; poses of bleeding disorders; abnormal coagulation parameters (prothrombin time and platelet count) ; systolic blood pressure more than 185 on the day of surgery; the patients who were taking aspirin or any kind of anticoagulant a week before the surgery; patients who had history of intracranial arteries surgery and also patients who their surgery will take 3 to 6 hours, will be excluded from study.
Brain Tumor; age range of 18 to 60 years; ASA class 1 or 2.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The amount of intraoperative bleeding. Timepoint: Every hour after the intervention. Method of measurement: Through suction container, the number of blood gases and also blood surgical field.
- Secondary Outcome Measures
Name Time Method Comparing EBL between the group which receives TXA and the control group, in patients undergoing craniotomy for tumor excision. Timepoint: 27 hours after the intervention. Method of measurement: Based on hemoglobin levels and by formulation.;Comparing the number of consumed packed cells , between the group which receives TXA and the control group, in patients undergoing craniotomy for tumor excision. Timepoint: 3-8 hours after the intervention. Method of measurement: counting the number of packed cells.;Comparing the amount of bleeding in mL, between the group which receives TXA and the control group, in patients undergoing craniotomy for tumor excision. Timepoint: Every hour after the intervention. Method of measurement: Through suction container, the number of blood gases and also blood surgical field.