The Potential use of Larval Therapy/Biogun and Silver to Reduce Colonisation of MRSA in Diabetic Foot Ulcers. - Use of Larvae/Biogun and Silver in Diabetic Foot Ulcers
- Conditions
- Methicillin Resistant Staphylococcus Aureus (MRSA)
- Registration Number
- EUCTR2007-002571-14-GB
- Lead Sponsor
- The University of Manchester
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Type 1 or 2 diabetes
Age 18-75
Active foot ulceration
Prsence of significant neuropathy: Vibration Perception Threshold > 25 volts and Neuropathy Disability Score >3/10
MRSA isolated from the active ulcer site on two consecutive specimens
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Presence of peripheral vascular disease requiring urgent surgical management
Wounds in which the MRSA is the primary infecying organism rather than colonisation
Known history of poor medical compliance
Wounds requiring systemic antibiotic treatment
Anti-coagulant therapy
Patients who do not consent
Pregnant or breastfeeding women
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The eradication of MRSA in diabetic foot ulcers;Secondary Objective: Time to eradication<br>Mechanism of action of larvae in eradicating MRSA;Primary end point(s): Eradication of MRSA from colonized diabetic foot ulcers
- Secondary Outcome Measures
Name Time Method