The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol
- Registration Number
- NCT00886860
- Lead Sponsor
- Mahidol University
- Brief Summary
The purpose of this study is to compare the efficacy for cervical ripening in labor induction between titrated and conventional oral misoprostol
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 64
Inclusion Criteria
- age 18 years old or more
- singleton pregnancy at 37 weeks gestation or more
- cephalic presentation
- reassuring fetal heart rate pattern
- admission for labor induction due to medical or obstetrical conditions
- bishop score less than 6
- giving consent and having signed the consent form for this study
Exclusion Criteria
- parity more than 3
- estimated fetal weight more than 3,500 grams
- non-reassuring fetal heart rate pattern
- having contraindication for vaginal delivery
- previous uterine scar
- suspected abruptio placenta with non-reassuring fetal heart rate pattern
- abnormal bleeding per vagina, except bloody show
- PROM
- having underlying cardiac, hepatic, or renal diseases
- having history of allergy to misoprostol or prostaglandin analogues
- cervical dilatation 3 centimeters or more
- uterine contraction 3 times or more in 10 minute
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description conventional oral misoprostol misoprostol misoprostol 50 micrograms oral every 4 hours until cervical dilatation 3 centimeters titrated oral misoprostol misoprostol misoprostol 20 micrograms oral every hour until cervical dilatation 3 centimeters
- Primary Outcome Measures
Name Time Method success rate of cervical ripening in labor induction 12 hours after intervention
- Secondary Outcome Measures
Name Time Method number of vaginal delivery 24 hours
Trial Locations
- Locations (1)
Siriraj Hospital, Mahidol University
🇹🇭Bangkok, Thailand