NCT00886860
Completed
Phase 4
The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol
Overview
- Phase
- Phase 4
- Intervention
- misoprostol
- Conditions
- Cervical Ripening
- Sponsor
- Mahidol University
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- success rate of cervical ripening in labor induction
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to compare the efficacy for cervical ripening in labor induction between titrated and conventional oral misoprostol
Investigators
Eligibility Criteria
Inclusion Criteria
- •age 18 years old or more
- •singleton pregnancy at 37 weeks gestation or more
- •cephalic presentation
- •reassuring fetal heart rate pattern
- •admission for labor induction due to medical or obstetrical conditions
- •bishop score less than 6
- •giving consent and having signed the consent form for this study
Exclusion Criteria
- •parity more than 3
- •estimated fetal weight more than 3,500 grams
- •non-reassuring fetal heart rate pattern
- •having contraindication for vaginal delivery
- •previous uterine scar
- •suspected abruptio placenta with non-reassuring fetal heart rate pattern
- •abnormal bleeding per vagina, except bloody show
- •having underlying cardiac, hepatic, or renal diseases
- •having history of allergy to misoprostol or prostaglandin analogues
- •cervical dilatation 3 centimeters or more
Arms & Interventions
conventional oral misoprostol
misoprostol 50 micrograms oral every 4 hours until cervical dilatation 3 centimeters
Intervention: misoprostol
titrated oral misoprostol
misoprostol 20 micrograms oral every hour until cervical dilatation 3 centimeters
Intervention: misoprostol
Outcomes
Primary Outcomes
success rate of cervical ripening in labor induction
Time Frame: 12 hours after intervention
Secondary Outcomes
- number of vaginal delivery(24 hours)
Study Sites (1)
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