Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients
Not Applicable
Completed
- Conditions
- Lung Transplant InfectionFungal Infection
- Interventions
- Other: collection of blood samples for PK testing
- Registration Number
- NCT01419678
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
This is a single center, observational study of posaconazole PK sampling in lung transplant recipients. The patients enrolled will have up to 6 (3ml) pk samples (a total of 18 ml) and one 10ml blood sample for a total collection of 28ml of blood obtained over the entire study. In addition, the investigators will collect medical record information and any excess BAL samples available during the study (tests done as part of the patient's clinical care and the samples would have been discarded once diagnosis was made).
- Detailed Description
PK blood samples will be obtained around a clinical dosing of posaconazole
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- 18 years of age and older receiving posaconazole post transplant as part of their care received a lung transplant
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Exclusion Criteria
- must meet inclusion criteria
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 'collection of blood samples for PK testing' collection of blood samples for PK testing collection of PK samples around a dosing of Posaconazole
- Primary Outcome Measures
Name Time Method measure the levels of posaconazole post dosing 24 hours after dosing pk samples will be obtained around dosing of medication and then analyzed for posaconazole levels
- Secondary Outcome Measures
Name Time Method determine the posaconazole concentration within the pulmonary epithelial lining fluid (ELF) and alveolar cells 1 year
Trial Locations
- Locations (1)
UPMC
🇺🇸Pittsburgh, Pennsylvania, United States