Effects of Trehalose on Peri-Trochanteric Fractures

Phase 3

Conditions: Peri-trochanteric fractures.
Pertrochanteric fracture
S72.1

Registration Number: IRCT20180404039188N5

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 64

Inclusion Criteria

Admission to the orthopedic department of Talaghani Hospital with a diagnosis of pertrochanteric fractures.
Age between 18 and 60 years.
Injury Severity Score (ISS) less than 15.
Willingness to cooperate and sign an informed consent form after full awareness of the study objectives and methods by the patient or their legal guardian.

Exclusion Criteria

Pregnancy and lactation.
Septic patients with unstable hemodynamics and metabolism.
History of autoimmune diseases or disorders.
History of cancer.
Chemotherapy and radiotherapy within the past month.
Diabetes mellitus
Any type of liver failure
Human immunodeficiency virus (HIV) infection.
Morbid obesity (BMI > 40)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of wound healing. Timepoint: At the beginning of the study, measurements are taken on the second day, in week 2 and week 4. Method of measurement: Wound healing index.;IL-6. Timepoint: At the beginning of the study, week 4 and week 12 measurements will be taken. Method of measurement: Measurement of serum levels of IL-6.

Secondary Outcome Measures

Name	Time	Method
ESR. Timepoint: at the beginning of study, week 4, week 12. Method of measurement: Measurement of serum levels of ESR.;CRP. Timepoint: at the beginning of the study, week 4, week 12. Method of measurement: Measurement of serum levels of CRP.;TNF-a. Timepoint: at the beginning of the study, week 4, week 12. Method of measurement: Measurement of serum levels of TNF-a.;CBC. Timepoint: at the beginnig of the study, week 4, week 12. Method of measurement: Blood test.