TO UNDERSTAND THE RELATION BETWEEN DURATION OF DIABETES AND KIDNEY PROBLEM WITH LAB REPORT

Not yet recruiting

• Conditions: Diabetes mellitus due to underlying condition with other specified complications,

• Registration Number: CTRI/2019/10/021675
• Lead Sponsor: Parul Institute of Ayurveda

Brief Summary

In Prameha all thedravadhatus in reference to kapha from shareera gets excreted through mutra.There is a significant change inphysical constitution, chemical contents and biochemical properties in suchmutra. The abnormal metabolic admixture of dustadosha, pradushtadhatu withmutra is nothing but pradusthita mutra or saama mutra. Therefore there is aextra addition of ama and its constituents to mutra which make mutra turnavila.

Normal value of GFR is 125ml/min. A stepwise increase in nitrogenousconstituents of blood like urea, creatinine etc and other biochemicalparameters like albumin, electrolytes etc also believed to reflectdeteriorating kidney function.

Renal involvement is a common complication and a leading cause of deathin diabetes which is classified under late systemic complications.

In chirakaaleena Pramehi dhatu excreted out with mutra can be consideredas samala mutrata or saghana mutrata which signifies the reduced GFR by kidneyslanding up in many renal dysfunctions.Since Cystatin-C is a small protein whichis produced constantly, freely filtered by glomerulus and also fully reabsorbedand broken down by renal tubules is considered as better marker for GFR thanSerum Creatinine.

In this research study the findings of Cystatin-C will help inunderstanding the relation between duration of Prameha vyadhi and Renaldysfunctions occurring in the same which will help in analyzing the involvementof mutravaha srotas.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-11-10
• Study Start: 2020-01-12

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Diagnosed patients of Prameha will be selected with symptoms Prabhoota and Avilamootrata & slight increase in quantity of urine associated with premonitory symptoms and symptoms of DM including Polyurea, Polydipsia, Polyphagia, Lassitude and Weightloss.

Exclusion Criteria

Thyroid dysfunctions, patients with cortico steroids therapy & chronic cigarette smokers Pregnancy with DM Systemic disorders hampering the kidney functions and other major disorders like TB,IHD,HIV associated with DM.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relation between duration of Prameha and renal dysfunction with Cystatin-C findings.	1 month

Secondary Outcome Measures

Name	Time	Method
To analyze the involvement of Mutravaha srotas in Prameha by considering Prabhoota and Availa mutra which signifies reduced GFR.	6 month

Trial Locations

Locations (1)

Parul Ayurveda Hospital; 🇮🇳 Vadodara, GUJARAT, India

Parul Ayurveda Hospital

🇮🇳Vadodara, GUJARAT, India

Dr Sachin Deva

Principal investigator

9844810957

sachin.deva@paruluniversity.ac.in