EUCTR2010-022763-35-AT进行中（未招募）不适用
Vitamin D supplementation in chronic heart failure: a randomized, double-blind, placebo-controlled trial
Medical University of Graz0 个研究点开始时间: 2011年1月4日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Chronic stable heart failure (NYHA II-IV, ejection fraction = 40%)
- •Non-ischemic etiology or ischemic etiology without severe advanced atherosclerosis (e.g. peripheral arterial disease stage IV)
- •= 45 years
- •25 (OH) Vitamin D = 30ng/ml
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •hypercalcemia (total serum calcium > 2.65 mmol/l OR ionized calcium > 1.35 mmol/l)
- •nephrocalcinosis, nephro-/urolithiasis (=1 year)
- •known granulomatous diseases (active tuberculosis, sarcoidosis)
- •allergy to cholecalciferol or placebo (oleum arachidis)
- •intake of magnesium, thiazide diuretics or cardiac glycosides
- •osteoporosis requiring standard therapy
研究者
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dHeart failure is a condition that occurs when the heart loses its normal ability to pump blood to maintain vital body functions and, therefore, works with lower efficiency. Several studies have shown that deficiency of vitamin D would delete the renin gene, regulate the myocytes growth and facilitate ventricular hypertrophy, favoring cardiovascular damage and the incidence of heart failure.MedDRA version: 14.1Level: SOCClassification code 10007541Term: Cardiac disordersSystem Organ Class: 10007541 - Cardiac disordersEUCTR2011-002823-16-ITA.O. UNIVERSITARIA INTEGRATA DI VERONA36