Effects of Transcutaneous Nervous Electric Stimulation (TENS) and Interferential Electrical Stimulation (IES) on the Autonomous Balance of Normotens Volunteers and Hypertensive Patients
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Healthy Volunteers
- 发起方
- Universidade Federal de Santa Maria
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Systemic arterial pressure (mmHg)
- 状态
- 已完成
- 最后更新
- 6年前
概览
简要总结
Hypertension is considered a serious public health problem. The imbalance in autonomic nervous system (ANS) activity is one of the main triggers in the development and maintenance of hypertension. The non-pharmacological management of this disease is an important resource, especially in refractory hypertensive patients or in hypertensive crises, where the pharmacological treatment does not present an efficient response. It is known that transcutaneous electrical nerve stimulation (TENS) is capable of modifying the autonomic balance, however, the effects of Interferential electrical stimulation (IES) on this system in normotensive and hypertensive volunteers are not yet known. These electrotherapeutic resources may be a non-pharmacological tool supporting the management of hypertension. The objective of this research is to study the effects of different TENS and IC parameters on cardiovascular variables of normotensive volunteers and hypertensive patients.
详细描述
Each volunteer will perform three assessments with a one-week interval. Each assessment will include assessment of autonomic balance, blood pressure, and blood collection (catecholamines). Interventions (placebo, low frequency TENS and IES) will be randomized. Volunteers will be accommodated in the supine position. With properly sanitized skin (70% alcohol) and self-adhesive electrodes (5x5 area) will be positioned in the cervical paravertebral region. All participants will be submitted to a placebo TENS session, a low frequency TENS session (TENS, 10 Hz/200μs) and an IES session (STEIN et al., 2012). The sessions will take place in the morning in a 12-hour fast, lasting 30 minutes, in an air-conditioned place (23ºC).
研究者
Luis Ulisses Signori
Principal Investigador
Universidade Federal de Santa Maria
入排标准
入选标准
- •Both sexes;
- •Normal blood pressure (PAS \<130 mmHg; PAD \<85 mmHg) or Previous Hypertension diagnosis, systolic blood pressure (SBP) \> 140 mm Hg and/or diastolic blood pressure (DBP) \>90 mm Hg and clinical stability with no change in medications for at least 2 months preceding the study;
- •The subjects that joined the study will be alphabetized volunteers;
- •Age between 20 and 65 years old;
- •With no symptoms of skeletal muscle disorders;
- •No previous performing cardiovascular surgery;
- •No previous diagnose of rheumatic, neurological, oncological, immune or hematologic diseases;
- •Without evidence of psychiatric diseases and/or cognitive déficit;
- •Non-Smoker;
- •Volunteers with a body mass index (BMI: kg/m2) greater than 35 will not be included in the study
排除标准
- •On the day of the assessments who have consumed of the alcoholic drink, caffeine and citrus juice and who have performed intense physical activities 48 before the examination
结局指标
主要结局
Systemic arterial pressure (mmHg)
时间窗: SBP will be evaluated 1 hours after the interventions
Systemic arterial pressure (SBP) will be evaluated by an Ambulatory Blood Pressure Monitor (ABPM) (NOBRE et al., 2011). Micromed and version 5.0.1.52 equipment will be used. Blood pressure monitoring using ABPM will be performed every 10 min throughout the experiment, which has an estimated time of two hours.
次要结局
- Heart Rate Variability (n.u.)(HRV will be evaluated 1 hours after the interventions)
- Blood collection - catecholamines (pg/mL)(Blood collection (catecholamines) will be evaluated 1 hours after the interventions)