on-invasive detection of potential epileptogenic cortical brain lesions

Recruiting

Conditions: convulsions
epilepsy
10039911

Registration Number: NL-OMON48843

Lead Sponsor: Stichting Epilepsie Instellingen Nederland

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

- Admitted to the epilepsy monitoring unit for presurgical evaluation
- Suspect superficial MRI region(s) reachable with TMS stimulation (depth < 3.5cm under the scalp)
- Aged 18 years or over
- Be able to understand the Dutch language
- Be able to understand the study (mentally capacitated)

Exclusion Criteria

- Pregnancy
- Mentally incapacitated
- Major radiological evidence of asymmetry between hemispheres
- Individuals with a cochlear implant, Pacemaker, deep brain stimulator or other implanted electronic devices
- Metal and/or metal fragments in head

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Positive predictive value of the TMS evoked seizures for successfully<br /><br>localizing the epileptogenic zone.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Congruency of the TMS evoked epileptiform abnormalities with the epileptogenic<br /><br>zone as determined in positive surgical outcome cases:<br /><br>- Epileptiform afterdischarges<br /><br>- TMS-EEG excitability parameters<br /><br><br /><br>Other parameters:<br /><br>- Type, depth and extension of lesion<br /><br>- Pathological assessment of lesion<br /><br>- Type of epilepsy, clinical semiology of seizures<br /><br>- Result of the pre-surgical evaluation<br /><br>- Post-surgical outcome</p><br>