Immunological correlates of protection against measles

Completed

• Conditions: immunity measles; 10047438

• Registration Number: NL-OMON32077
• Lead Sponsor: RIVM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 750

Inclusion Criteria

Children aged 4 - 8 years

Exclusion Criteria

Children twice vaccinated with MMR vaccination

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Identification of serological (measles neutralizing antibodies and IgG)<br /><br>correlates of protection against clinical measles and measles virus infection. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* To study a measles IgG correlate for protection in oral fluid;<br /><br>* To describe measles compatible symptoms among once vaccinated individuals who<br /><br>seroconvert to measles but do not meet the clinical case definition<br /><br>(*attenuated measles*);<br /><br>* To assess the attack rate of measles symptoms in the study population.<br /><br>* To assess the degree of underdiagnosis, underreporting and the burden of<br /><br>disease of measles in the study population.</p><br>