Treatment of severely fatigued adolescents with an immune dysregulation disorder

Completed

• Conditions: Immune dysregulation disorder; Haematological Disorders

• Registration Number: ISRCTN12612526
• Lead Sponsor: niversity Medical Center Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-11
• Last Update Posted: 8 May 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. Age of 11.5 - 18 years old
2. Able to speak, read, and write Dutch
3. Diagnosed with JIA, JDM or CVID
4. Being severely fatigued for at least 3 months (CIS fatigue = 40)
5. Physical functioning subscale (Child Health Questionnaire) score = 85 and/or school absence > 10%
6. At least 3 months before treatment on stable medication (type and dosage)
7. Diagnosed with unexplained fatigue by the general paediatrician

Exclusion Criteria

1. Suspicion of active disease requiring adaptation of treatment (at the time of inclusion) or a possible visit to the paediatric rheumatologist (during treatment)
2. Cognitive impairment, estimated IQ <70
3. A somatic cause assessed by the general paediatrician or co-morbid psychiatric disorder based on questionnaires that can explain fatigue at baseline assessment before the start of CBT
4. An anxiety score above 44 on the Spielberger State-Trait Anxiety Inventory for Children (STAIC), (average score of Dutch healthy adolescents plus 2 SD)
5. A depression score above 15 on the Children’s Depression Inventory (CDI), (average score of Dutch healthy adolescents plus 2 SD)
6. Presence of suicidal risk, as assessed by CDI and general paediatrician
7. Receiving treatment for a psychiatric disorder at time of inclusion
8. No availability of computer with internet access

Study & Design

• Study Type: Interventional
• Study Design: Not specified