Anti KU Antibodies and Its Relationship With Systemic Lupus Erythematosus
- Conditions
- Systemic Lupus Erythematosus
- Registration Number
- NCT05900232
- Lead Sponsor
- Sohag University
- Brief Summary
systemic lupus Erythematosus (SLE) is a multi system autoimmune disorder abroad spectrum of clinical presentations.
Diagnosis of SLE depending on Systemic Lupus International Collaborating Clinics (SLICC) Criteria.
SLICC Criteria requires either that a patient satisfy at least 4 of 17 Criteria including at least 1 of 11 clinical criteria and 1 of 6 immunological criteria or the patient has biopsy -proven nephritis compatible with SLE in the presence of antinuclear antibodies (ANA)or anti_double stranded DNA (dsDNA) antibodies.
Anti_KU antibodies included in (ANA), reported in many autoimmune disorders like SLE,Sjogren syndrome, idiopathic lung fibrosis and myositis.
So the aim of the work is to determine the relationship between Anti_KU antibodies and SLE manifestations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- all patients will fulfill the Systemic Lupus International Clinics(SLICC) classification criteria for Systemic Lupus Erythematosus.
- any patient with any collagen disease other than SLE
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Anti KU antibodies and its relationship with Systemic Lupus Erythematosus manifestations 6 months the study will evaluate the titre of Anti KU
antibodies which is positive or negative in one patient and on the other side what is the manifestation of SLE that found in the same patient if the Anti KU Antibodies titre is positive
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag University Hospitals
🇪🇬Sohag, Egypt