The MOA trial – Management of OsteoArthritis by exercise therapy and/or manual physiotherapy in addition to usual care

Phase 3

Completed

• Conditions: Osteoarthritis/Hip; Osteoarthritis/Knee; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12608000130369
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-03-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

Patients referred for an orthopaedic consultation for hip or knee osteoarthritis and consideration for joint replacement surgery and who meet clinical criteria for diagnosis of osteoarthritis of the hip or knee according to American College of Rheumatology criteria

Exclusion Criteria

- Previous knee or hip joint surgery;
- any other surgical procedure of the lower limbs in the prior 6 months;
- initiation of opioid analgesia or cortico-steroid or analgesic injection intervention for hip or knee pain within prior 30 days;
- rheumatoid arthritis of the hip or knee;
- physical impairments preventing safe participation in exercise, manual therapy, walking or stationary cycling, such as: uncontrolled hypertension or AHA risk-rating of A3B or higher; vision problems that affect mobility, neurogenic disorder, primary or debilitating back pain, advanced osteoporosis, body mass >155kg, unable to ambulate 10m without an assistive device;
- insufficient communication ability to comprehend or comply with assessment interventions;
- stated inability to complete the proposed course of intervention and follow-up.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Western Ontario and McMaster Osteoarthritis Index (WOMAC) composite score[1 year]

Secondary Outcome Measures

Name	Time	Method
40m self-paced walk test[1 year];Outcome Measures in Rheumatoid Arthritis Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) responder criteria[1 years];Undergone joint replacement surgery[2 year];Costs assessed by patient self-report questionnaire and healthcare records[2 years];SF-12v2 (Quality Metric, Inc.)[1 and 2 years];WOMAC pain subscale[1 year];Patient-rated assessment of global improvement (using the Global Rating of Change instrument)[1 year];Numeric Pain Rating Scale[1 year];Timed up-and-go test (timed physical performance test: patient stands from a chair, walks 3 metres, returns and sits back down in chair.)[1 year];30 second sit-to-stand test[1 year];WOMAC physical function subscale[1 year]