NCT07701603尚未招募不适用
Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 16
- 主要终点
- Diaphragm contractility
研究概览
简要总结
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non.smoking
- •normal lung function
- •BMI: 18.5-29.9 kg/m2
- •willing to adhere to study rules
排除标准
- •Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- •Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- •Any metal or electronics inside of the body
- •Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- •History of seizures or epilepsy
- •Tattoos on the stimulation sites
- •Previous enrolment in this study
- •For women: Pregnancy, breastfeeding, or intention to become pregnant during the study
研究组 & 干预措施
Gas perturbations
Experimental
Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h.
干预措施: Gas perturbation (Other)
结局指标
主要结局
Diaphragm contractility
时间窗: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec
Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.
次要结局
未报告次要终点
研究者
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