A Study in Overweight And Obesity (Grade 1) Phenotypes Of Different Deha Prakriti To assess Metabolomic Variations For Risk Predictions And Precise Therapeutic Pathway : An Exploratory Observational And Bio Molecular Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. Identification of variations in metabolites & metabolomic pathways in overweight & obesity (Grade 1) individuals of different Deha Prakriti
研究概览
简要总结
Background:
Obesity is a growing global health challenge, with significant variation in risk profiles and therapeutic responses. Ayurveda describes Deha Prakriti (individual constitutional types) as determinants of susceptibility to diseases and treatment outcomes. Modern metabolomics offers a tool to understand biochemical variations at a molecular level.
Aim:
To explore the association between Deha Prakriti phenotypes and metabolomic variations in Grade-1 overweight and obese individuals, in order to predict disease risks and design precise therapeutic pathways.
Study Design:
Exploratory, observational study.
Participants: Adults with Grade-1 overweight/obesity.
Methods:
Assessment of Deha Prakriti (Ayurvedic constitution typing).
Phenotypic profiling of overweight/obesity.
Bio-molecular analysis using metabolomic techniques.
Correlation of molecular signatures with Prakriti types.
Expected Outcomes:
Identification of metabolomic markers associated with Deha Prakriti.
Early risk prediction for metabolic disorders in overweight and obesity.
Insights for personalized, Prakriti-based therapeutic strategies integrating Ayurveda and molecular biology.
Significance:
This study bridges traditional Ayurvedic wisdom with modern biomolecular science, paving the way for personalized and predictive medicine in obesity management.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Apparently overweight and obesity (Grade 1) individuals of age 18 to 40 years irrespective of gender and occupation BMI 23 to 24.9 kg per m² (overweight) and BMI 25 to 29.9 Obesity (Grade 1) Any participant currently using weight loss medication or following any other weight loss protocols of dieting should be included only after following a 3 week washout protocol However the patients habituated with exercise protocols maybe included without wash out period Individuals willing to give consent.
排除标准
- •Having any comorbid conditions viz.
- •Diabetes Mellitus and Hypertension and cardiovascular diseases or major systemic illnesses Participants with current use of weight-loss medications or following any other weight loss protocols of dieting if are not willing for the wash out period of 21 days maybe excluded Pregnant or lactating women.
- •• Any women participant with perimenopausal, menopausal or post menopausal symptoms.
- •• Allergy to any ingredients of Yava- Amalak Churna.
结局指标
主要结局
1. Identification of variations in metabolites & metabolomic pathways in overweight & obesity (Grade 1) individuals of different Deha Prakriti
时间窗: Metabolomic Assay will be performed after 1 month
2. Discovery of potential metabolic biomarkers for obesity risk prediction in over-weight & Obesity (Grade 1) individuals.
时间窗: Metabolomic Assay will be performed after 1 month
3. Generating evidence of differential metabolic pathways to Yava Amalak Churna across Prakriti groups in over-weight & Obesity (Grade 1) individuals
时间窗: Metabolomic Assay will be performed after 1 month
次要结局
未报告次要终点
研究者
Dr Akanksha Pundir
All India Institute Of Ayurveda New Delhi