Metformin improves arterial stiffness and endothelial function in young women with polycystic ovary syndrome: a randomised crossover trial

Cardiff University (UK)0 个研究点目标入组 32 人开始时间: 2009年6月25日最近更新: 2019年9月2日

适应症

试验速览

•1. From the Endocrinology clinics at the University Hospital of Wales
•2. Diagnosed with PCOS, based on androgen excess (clinical symptoms of hyperandrogenism and/or elevated testosterone) with ovulatory dysfunction (fewer than six menstrual cycles per year), supported by ovarian ultrasound where available
•3. Congenital adrenal hyperplasia, Cushings syndrome, androgen-secreting neoplasms, hyperprolactinaemia and thyroid disease excluded by biochemical testing
•4. Aged between 18 and 35 years

•1. Pregnant
•2. Breastfeeding
•3. History of current or previous use (within 6 months) of oral contraceptives, anti-diabetics or anti-androgens
•4. Contraindications to metformin therapy including renal or hepatic impairment, ketoacidosis, or conditions where tissue hypoxia is likely (e.g. sepsis, respiratory failure, recent myocardial infarction)
•5. History of hypertension or diabetes
•6. Able to use barrier methods of contraception if sexually active. In addition, pregnancy tests were performed at each study visit and patients were withdrawn from the study in the event of confirmed pregnancy.

发起方

Cardiff University (UK)