The Effect of Two Different Types of Forces on Possible Root Resorption in Relation to Dentin Phosphoprotein Levels

Not Applicable

Completed

• Conditions: Root Resorption
• Interventions: Other: Intermittent force; Other: Continuous force

• Registration Number: NCT04825665
• Lead Sponsor: Sherifa Ghaleb

Brief Summary

External root resorption is a common unfavourable sequel of orthodontic treatment. Although diagnosis of root resorption is usually done by radiographs; they are technique sensitive. Dentine phosphoprotein, a non-collagenous protein, is suggested to be released into the gingival crevicular fluid during active root resorption, serving as a good diagnostic tool. Also, the manner of force application is a modifiable factor suggested to affect root resorption.

Detailed Description

Early detection of teeth at risk of severe resorption is crucial.At present, using radiographs is common but detecting only resorption after 60-70% of the mineralized tissue is already lost. Moreover, they only provide two-dimensional information, identifying apical change primarily. Also, radiographs cannot indicate if the process of root resorption is still active for monitoring its progress and additional radiation exposure to the patient will be needed. Therefore, a safer, more reliable alternative method to clinically diagnose early stages of root resorption is needed and may include detecting biomarkers in gingival crevicular fluid. Furthermore, the relationship between the manner of orthodontic force application and orthodontically induced root resorption is under study. It has been suggested that pausing orthodontic forces during treatment may reduce the amount of root resorption, likely due to cementum repair during the inactive period. This is important specifically in individuals who are biologically and genetically prone to root resorption. The aim of the study is to compare the extent of root resorption between controlled continuous and intermittent orthodontic forces using levels of dentin phosphoprotein in gingival crevicular fluid.

Study Timeline

• Study Start: 2020-03-17
• Primary Completion: 2021-02-18
• Study First Submitted: 2021-03-29
• Study First Submitted QC: 2021-03-29
• Study First Posted: 2021-04-01
• Study Completion: 2021-04-14
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-19
• Last Update Posted: 2021-07-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Malocclusion that requires extraction of first maxillary premolars on both sides.
• No previous reported or observed dental treatment to the teeth to be extracted.
• No previous reported or observed trauma to the teeth to be extracted.
• No previous reported or observed orthodontic treatment involving the teeth to be extracted.
• Free of any systemic disease affecting the dentition.

Exclusion Criteria

• Past or present signs or symptoms of periodontal disease.
• Past or present signs or symptoms of bruxism.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intermittent force	Intermittent force	A buccally directed tipping force of 150 g removed every 21 days for a 7-day rest period applied to the maxillary first premolar on one side
Continuous force	Continuous force	A buccally directed continuous tipping force of 150 g is applied to the maxillary first premolar on one side

Primary Outcome Measures

Name	Time	Method
Dentin Phosphoprotein levels	2 months	Evaluate and compare the possible effect of continuous and intermittent orthodontic forces on root resorption using dentin phosphoprotein levels.

Trial Locations

Locations (2)

Faculty of Dentistry,Alexandria University; 🇪🇬 Alexandria, Please Select A Region, State Or Province., Egypt

Faculty of Dentistry, Alexandria University; 🇪🇬 Alexandria, Egypt