Efficacy of Repyflec Cognitive Remediation Group Training in Cognition, Functional Outcomes and Psychiatric Symptoms of Outpatients With Schizophrenia.
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Indication for Modification of Patient Cognitive Status
- Sponsor
- Fundació Sant Joan de Déu
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Executive Function
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study was to develop an integrative intervention for schizophrenia taking into account previous efficacious therapies. Thus, our aim was to evaluate the efficacy of our cognitive remediation group training: Problem Solving and Cognitive Flexibility training (REPYFLEC), focused to improve neurocognition and functioning in schizophrenia patients. We hypothesized that training executive function and metacognition would allow us to achieve improvements in neurocognition, functioning and psychiatric symptoms of patients with schizophrenia.
Investigators
Aida Farreny
Dr. Aida Farreny
Fundació Sant Joan de Déu
Eligibility Criteria
Inclusion Criteria
- •Diagnosis of schizophrenia or schizoaffective disorder
- •More than 2 years illness duration
- •Mini Mental Status Examination score over 24
- •Global Assessment of Functioning scores between 40 and 70
Exclusion Criteria
- •Current acute illness exacerbation
- •Mental Retardation
- •Neurological disorder which impairs cognition
- •Currently participating in social skills training or cognitive remediation
- •Change of antipsychotic medication one month before the trial or during the 40 study weeks
- •Diagnosis of alcohol or drug dependence within 6 months of trial commencement.
Outcomes
Primary Outcomes
Executive Function
Time Frame: Change from baseline in executive functioning at 40 weeks
Behavioral Assessment of the Dysexecutive Syndrome (BADS) (Wilson et al., 1996). This scale evaluates cognitive flexibility, inhibition of impulsive responses, planning and organization, working memory and time-estimation capacity. All subscales (Rule shift cards, Action Program, Key search, Temporal judgement, Zoo map and Six elements) were administered. We used subscales raw scores which run from 0 to 4. The subscales' raw score is summarized and converted to standardized total score which run (min. 12-max. 129). A higher score indicates better performance.
Secondary Outcomes
- Psychosocial Functioning(Change from baseline in social functioning scales at 40 weeks)
- Psychiatric Symptoms(Change from baseline in psychiatric symptoms scales at 40 weeks)