The effects of Resveratrol on expression of some ER stress pathway genes in granulosa cells and some circulating inflammatory markers in PCOS patients

Vice chancellor for research of Tehran University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新: 2018年2月22日

试验速览

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•Inclusion Criteria: Infertility with documented PCOS based on Rotterdam criteria; 18-40 Y/O; If have male factor; it must be mild to moderate form, not non-obstructive azospermia; If have other female factor; only cervical & tubal factors are acceptable; Candidate for IVF Cycle; No insulin taking history; Not eating red grapes, pistachio, peanut and berries recently.

•Diseases due to obesity with unknown cause (Hypothyroidism, Coshing Syndrome); . FSH>10 at third day of the cycle; Severe endometriosis (Stage III or IV); Thyroid diseases; Congenital Adrenal Hyperplasia; Hyperprolactinemia; Ovarian Tumors; Taking Steroids, OCP and other drugs that affect ovarian function, insulin sensitivity or lipid metabolism in past 3 months (except routin PCOS therapy); SLE (Systemic Lupus Erythematosus) & autoimmune diseases; Systemic diseases like Metabolic Syndrome, Hyperlipidemias & cardiovascular diseases; Severe male factor like non-Obstructive Azospermia (sperm concentration < 5 mill/m); Patients who use vitrification method to avoid OHSS; Having alergy to some fruits like red grapes, pistachio and red berry; Insulin taking history

发起方

Vice chancellor for research of Tehran University of Medical Sciences