Training to improve glucose control and cardiac fitness for patients with Type 2 Diabetes
- Conditions
- Health Condition 1: null- Type 2 Diabetes Mellitus
- Registration Number
- CTRI/2017/08/009459
- Lead Sponsor
- Jamia Millia Islamia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
1. Sedentary defined as not exercising more than 20 minutes on 3 or more days a week
2. Diabetes diagnosis > 1 year.
3. Already receiving oral anti-diabetic medications but have HbA1c levels 6.5-10%
4. Able to walk continuously for at least 20 min and climb one flight of stairs unaided without stopping
1. BMI > 43kg/m2
2. Subjects on exogenous insulin
3. Retinopathy, nephropathy and neuropathy
4. Inflammatory and other conditions potentially associated with altered cytokine regulation
5. Autoimmune diseases
6. Hypothyroidism
7. Osteoporosis
8. Liver impairment
9. Renal insufficiency (creatinine levels > 2.0 mg/dl)
10. Diagnosed cardiovascular disease
11. Recent onset of cardiac-origin symptoms
12. Been prescribed a very low caloric diet (less than 1000 kcal/day) or drugs for the treatment of obesity
13. Orthopaedic problems limiting physical activity
14. Those already doing intensive physical activity > 2 h/week.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vo2 max <br/ ><br>Oxygen Uptake Kinetics <br/ ><br>Heart Rate Recovery <br/ ><br>HbA1c <br/ ><br>Blood glucose <br/ ><br>Antioxidant enzymes (GPX, SOD, CAT) <br/ ><br>Timepoint: Baseline (0 week) <br/ ><br>12 weeks
- Secondary Outcome Measures
Name Time Method BMI <br/ ><br>Skin fold measurement <br/ ><br>Waist circumference <br/ ><br>Waist- Hip ratio <br/ ><br>BP <br/ ><br>Lipid profile (Total cholesterol, HDL, LDL)Timepoint: Baseline (0 week) <br/ ><br>12 weeks