Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Mayo Clinic
- Enrollment
- 50
- Locations
- 2
- Primary Endpoint
- Arterial stiffness
Study Overview
Brief Summary
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
- •For controls: no cardiac disease history
Exclusion Criteria
- •Pregnancy
- •Known or suspected unstable cardiac condition within 4 weeks of the study
- •Active treatment with anticoagulation or dual antiplatelet therapy
Arms & Interventions
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Carotid Ultrasounds (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Elastography (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Arterial Tonometry (Other)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Echocardiogram (Diagnostic Test)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Ankle-Brachial Index (Other)
Spontaneous coronary artery dissection (SCAD) group
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Microneurography with sympathoexcitatory maneuvers (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Arterial Tonometry (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Echocardiogram (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Carotid Ultrasounds (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Elastography (Diagnostic Test)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Ankle-Brachial Index (Other)
Healthy Control Group
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Intervention: Microneurography with sympathoexcitatory maneuvers (Other)
Outcomes
Primary Outcomes
Arterial stiffness
Time Frame: Baseline
Measured by carotid ultrasound pulse wave velocity reporting in m/s
Sympathetic response to stress
Time Frame: Baseline
Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Arterial thickness
Time Frame: Baseline
Measured by carotid ultrasound intimal media thickness reporting in mm
Baroreflex sensitivity
Time Frame: Baseline
The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)
Secondary Outcomes
No secondary outcomes reported
Investigators
Marysia Tweet
Principal Investigator
Mayo Clinic