MedPath

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

Phase 3
Recruiting
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
Registration Number
NCT06890598
Lead Sponsor
Eli Lilly and Company
Brief Summary

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
700
Inclusion Criteria
  • Histological or cytological confirmation of NSCLC.

    • Part A

      1. Clinical Stage II-IIIB (N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
      2. Pathologic Stage II-IIIB (N2) NSCLC treated with initial upfront resection.
    • Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy.

  • Must have disease with evidence of KRAS G12C mutation.

  • Must have known programmed death-ligand 1 (PD-L1) expression

  • Must have an ECOG performance status of 0 or 1.

  • Able to swallow oral medication.

  • Must have adequate laboratory parameters.

  • Contraceptive use should be consistent with local regulations for those participating in clinical studies.

  • Women of childbearing potential must

    • Have a negative pregnancy test.
    • Not be breastfeeding during treatment
Exclusion Criteria
  • Have known changes in the EGFR or ALK genes.
  • Have another type of cancer that is progressing or required active treatment within the past 3 years before screening.
  • Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
  • Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Part A: Olomorasib + PembrolizumabOlomorasibParticipants will receive olomorasib administered orally in combination with pembrolizumab intravenously (IV) for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Part A: Olomorasib + PembrolizumabPembrolizumabParticipants will receive olomorasib administered orally in combination with pembrolizumab intravenously (IV) for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Part A: Placebo + PembrolizumabPembrolizumabParticipants will receive placebo administered orally in combination with pembrolizumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Part A: Placebo + PembrolizumabPlaceboParticipants will receive placebo administered orally in combination with pembrolizumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Part B: Olomorasib + DurvalumabOlomorasibParticipants will receive olomorasib administered orally in combination with durvalumab administered IV for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Part B: Olomorasib + DurvalumabDurvalumabParticipants will receive olomorasib administered orally in combination with durvalumab administered IV for up to 1 year followed by olomorasib alone for up to 3 years of total treatment.
Part B: Placebo + DurvalumabDurvalumabParticipants will receive placebo administered orally in combination with durvalumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Part B: Placebo + DurvalumabPlaceboParticipants will receive placebo administered orally in combination with durvalumab administered IV for up to 1 year followed by placebo alone for up to 3 years of total treatment.
Primary Outcome Measures
NameTimeMethod
Part A: Disease-Free Survival (DFS) by Investigator AssessmentRandomization to disease recurrence or death from any cause (Estimated as approximately 48 months).

DFS by Investigator Assessment

Part B: Progression-Free Survival (PFS)Randomization to disease progression or death from any cause (Estimated as approximately 3 years).

PFS per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by blinded independent central review (BICR)

Secondary Outcome Measures
NameTimeMethod
Part A & B: Overall Survival (OS)Randomization to disease progression or death from any cause (Estimated as approximately 5 years).

OS

Part A & B: Change from baseline in health-related quality of life (HRQoL), measured by European Organization for Research & Treatment of CancerQualityofLifeQuestionnaire-Core 30 (EORTC QLQ-C30)Randomization through end of treatment (Estimated as approximately 3 years).

Change from baseline in HRQoL, measured by the EORTC QLQ-C30

Part B: Objective Response Rate (ORR) per RECIST 1.1 by BICRRandomization to disease progression or death from any cause (Estimated as approximately 3 years).

ORR per RECIST 1.1 by BICR

Part B: Duration of Response (DOR) per RECIST 1.1 by BICRRandomization to disease progression or death from any cause (Estimated as approximately 3 years).

DOR per RECIST 1.1 by BICR

Part B: Disease Control Rate (DCR) per RECIST 1.1 by BICRRandomization to disease progression or death from any cause (Estimated as approximately 3 years).

DCR per RECIST 1.1 by BICR

Part B: Time to Response (TTR) per RECIST 1.1 by BICRRandomization until the date that measurement criteria for CR or PR (whichever is first recorded) are first met (Estimated as approximately 3 years).

TTR per RECIST 1.1 by BICR

Part B: Progression-Free Survival 2 (PFS2) by investigator assessmentRandomization to disease progression on next line of treatment or death from any cause (Estimated as approximately 3 years).]

PFS2 by investigator assessment

Part B: Changes in Non-Small Cell Lung Cancer (NSCLC)-related symptoms, measured by the NSCLC-Symptom Assessment Questionnaire (SAQ)Randomization through end of treatment (Estimated as approximately 3 years).

Changes in NSCLC-related symptoms, measured by the NSCLC-SAQ

Part B: Time to worsening of NSCLC-related symptoms, as measured by NSCLC-SAQRandomization through end of treatment (Estimated as approximately 3 years).

Time to worsening of NSCLC-related symptoms, as measured by NSCLC-SAQ

Part B: Changes in patient-reported pulmonary symptoms of cough, chest pain, and dyspnea, measured by NSCLC-SAQRandomization through end of treatment (Estimated as approximately 3 years).

Changes in patient-reported pulmonary symptoms of cough, chest pain, and dyspnea, measured by NSCLC-SAQ

Trial Locations

Locations (321)

Clearview Cancer Institute

🇺🇸

Huntsville, Alabama, United States

The University of Arizona Cancer Center - North Campus

🇺🇸

Tucson, Arizona, United States

Highlands Oncology Group

🇺🇸

Springdale, Arkansas, United States

UCLA Hematology/Oncology - Santa Monica

🇺🇸

Los Angeles, California, United States

Profound Research LLC

🇺🇸

Oceanside, California, United States

Stanford Cancer Center

🇺🇸

Palo Alto, California, United States

Kaiser Permanente San Diego Mission Road

🇺🇸

San Diego, California, United States

BASS Cancer Center

🇺🇸

Walnut Creek, California, United States

Hartford Hospital (HH)

🇺🇸

Hartford, Connecticut, United States

Boca Raton Regional Hospital

🇺🇸

Boca Raton, Florida, United States

Florida Cancer Specialists - South

🇺🇸

Fort Myers, Florida, United States

University of Florida - Jacksonville

🇺🇸

Jacksonville, Florida, United States

Miami Cancer Institute at Baptist Health, Inc.

🇺🇸

Miami, Florida, United States

Florida Cancer Specialists North

🇺🇸

Saint Petersburg, Florida, United States

Moffitt Cancer Center

🇺🇸

Tampa, Florida, United States

Florida Cancer Specialists East

🇺🇸

West Palm Beach, Florida, United States

University of Illinois at Chicago

🇺🇸

Chicago, Illinois, United States

University of Chicago Medical Center

🇺🇸

Chicago, Illinois, United States

Springfield Clinic Main Campus

🇺🇸

Springfield, Illinois, United States

Parkview Research Center at Parkview Regional Medical Center

🇺🇸

Fort Wayne, Indiana, United States

Franciscan Health

🇺🇸

Indianapolis, Indiana, United States

The University of Kansas Cancer Center - Westwood

🇺🇸

Westwood, Kansas, United States

Baptist Health Lexington

🇺🇸

Lexington, Kentucky, United States

CHI Saint Joseph Cancer Center - East

🇺🇸

Lexington, Kentucky, United States

Mary Bird Perkins Cancer Center

🇺🇸

Baton Rouge, Louisiana, United States

Ochsner Clinic Foundation

🇺🇸

New Orleans, Louisiana, United States

University of Maryland

🇺🇸

Baltimore, Maryland, United States

Reliant Medical Group

🇺🇸

Worcester, Massachusetts, United States

Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

University of Missouri Hospital

🇺🇸

Columbia, Missouri, United States

Saint Louis University Cancer Center

🇺🇸

Saint Louis, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

Columbia University Irving Medical Center

🇺🇸

New York, New York, United States

Memorial Sloan Kettering Cancer Center

🇺🇸

New York, New York, United States

Cleveland Clinic

🇺🇸

Cleveland, Ohio, United States

Providence Portland Medical Center

🇺🇸

Portland, Oregon, United States

Providence St. Vincent Medical Center

🇺🇸

Portland, Oregon, United States

Kaiser Permanente Interstate Medical Office Central

🇺🇸

Portland, Oregon, United States

Oregon Health and Science University

🇺🇸

Portland, Oregon, United States

Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office

🇺🇸

Philadelphia, Pennsylvania, United States

AHN Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Medical University of South Carolina

🇺🇸

Charleston, South Carolina, United States

Lexington Medical Center

🇺🇸

West Columbia, South Carolina, United States

Tennessee Oncology Chattanooga

🇺🇸

Chattanooga, Tennessee, United States

University of Tennessee Medical Center

🇺🇸

Knoxville, Tennessee, United States

Sarah Cannon Research Institute

🇺🇸

Nashville, Tennessee, United States

SCRI Oncology Partners

🇺🇸

Nashville, Tennessee, United States

Tennessee Oncology

🇺🇸

Nashville, Tennessee, United States

University of Texas MD Anderson Cancer Center

🇺🇸

Houston, Texas, United States

USO - Texas Oncology - San Antonio

🇺🇸

San Antonio, Texas, United States

USO - Texas Oncology Gulf Coast

🇺🇸

Sugar Land, Texas, United States

USO - US Oncology Research Network

🇺🇸

The Woodlands, Texas, United States

University of Virginia Health System

🇺🇸

Charlottesville, Virginia, United States

VCU Health Adult Outpatient Pavillion

🇺🇸

Richmond, Virginia, United States

Swedish Medical Center

🇺🇸

Seattle, Washington, United States

Cancer Care Northwest - Vercler

🇺🇸

Spokane Valley, Washington, United States

Northwest Cancer Specialists PC

🇺🇸

Vancouver, Washington, United States

Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

Tamworth Hospital

🇦🇺

North Tamworth, New South Wales, Australia

Icon Cancer Centre Wesley

🇦🇺

Auchenflower, Queensland, Australia

Sunshine Coast University Hospital

🇦🇺

Birtinya, Queensland, Australia

ICON Cancer Centre - Kurralta Park

🇦🇺

Kurralta Park, South Australia, Australia

Austin Health

🇦🇺

Heidelberg, Victoria, Australia

Goulburn Valley Health

🇦🇺

Shepparton, Victoria, Australia

Latrobe Regional Health

🇦🇺

Traralgon, Victoria, Australia

Ordensklinikum Linz GmbH Elisabethinen

🇦🇹

Linz, Oberösterreich, Austria

Ospedale San Gerardo-ASST Monza

🇮🇹

Monza, Lombardia, Italy

Medizinische Universität Graz

🇦🇹

Graz, Steiermark, Austria

Klinik Floridsdorf

🇦🇹

Wien, Austria

Antwerp University Hospital

🇧🇪

Edegem, Antwerpen, Belgium

CHIREC - site delta

🇧🇪

Auderghem, Bruxelles-Capitale, Région De, Belgium

UZ Leuven

🇧🇪

Leuven, Vlaams-Brabant, Belgium

AZ Delta vzw

🇧🇪

Roeselare, West-Vlaanderen, Belgium

Centro de Pesquisa Clínica do Instituto do Câncer do Ceará

🇧🇷

Fortaleza, Ceará, Brazil

Oncocentro de Minas Gerais

🇧🇷

Belo Horizonte, Minas Gerais, Brazil

Hospital de Cancer de Londrina

🇧🇷

Londrina, Paraná, Brazil

CTO - Centro de Tratamento Oncológico

🇧🇷

Belem, Pará, Brazil

Liga Norte Riograndense Contra o Câncer

🇧🇷

Natal, Rio Grande Do Norte, Brazil

Hospital Tacchini

🇧🇷

Bento Gonçalves, Rio Grande Do Sul, Brazil

Hospital São Lucas da PUCRS

🇧🇷

Porto Alegre, Rio Grande Do Sul, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos

🇧🇷

Barretos, São Paulo, Brazil

Centro de Pesquisa Sao Lucas

🇧🇷

Campinas, São Paulo, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR)

🇧🇷

Sao Paulo, São Paulo, Brazil

Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA

🇧🇷

Rio de Janeiro, Brazil

Instituto D'Or Pesquisa e Ensino

🇧🇷

Rio de Janeiro, Brazil

Icesp - Instituto Do Câncer Do Estado de São Paulo

🇧🇷

São Paulo, Brazil

Hospital Santa Catarina - Paulista

🇧🇷

São Paulo, Brazil

Centro Paulista de Oncologia Clínica

🇧🇷

São Paulo, Brazil

Anhui Medical University - Anhui Chest Hospital

🇨🇳

Hefei, Anhui, China

Cancer Hospital Chinese Academy of Medical Science

🇨🇳

Beijing, Beijing, China

China-Japan Friendship Hospital

🇨🇳

Beijing, Beijing, China

Peking University People's Hospital

🇨🇳

Beijing, Beijing, China

Beijing Cancer hospital

🇨🇳

Beijing, Beijing, China

The Second Affiliated Hospital Chongqing Medical University

🇨🇳

Chongqing, Chongqing, China

The First People's Hospital of Foshan

🇨🇳

Foshan, Guangdong, China

Guangdong Provincial People's Hospital

🇨🇳

Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou Medical University

🇨🇳

Guangzhou, Guangdong, China

Cancer Hospital of Shantou University Medical College

🇨🇳

Shantou, Guangdong, China

ShenZhen People's Hospital

🇨🇳

Shenzhen, Guangdong, China

Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center

🇨🇳

Shenzhen, Guangdong, China

Zhongshan Peoples Hospital

🇨🇳

Zhongshan, Guangdong, China

Liuzhou People's Hospital

🇨🇳

Liuzhou, Guangxi, China

Guangxi Medical University Affiliated Tumor Hospital

🇨🇳

Nanning, Guangxi, China

Harbin Medical University Cancer Hospital

🇨🇳

Harbin, Heilongjiang, China

Anyang Cancer Hospital

🇨🇳

Anyang, Henan, China

The First Affiliated Hospital of Henan University of Science &Technology

🇨🇳

Luoyang, Henan, China

Tongji Hospital Tongji Medical,Science & Technology

🇨🇳

Wuhan, Hubei, China

Hubei Cancer Hospital

🇨🇳

Wuhan, Hubei, China

Xiangya Hospital Central South University

🇨🇳

Changsha, Hunan, China

Hunan Cancer Hospital

🇨🇳

Changsha, Hunan, China

ZhuZhou Central Hospital

🇨🇳

Zhuzhou, Hunan, China

The First Affiliated Hospital of Soochow University

🇨🇳

Suzhou, Jiangsu, China

Jilin Cancer Hospital

🇨🇳

Changchun, Jilin, China

The First Affiliated Hospital of Xi'an Jiaotong University

🇨🇳

Xi'an, Shaanxi, China

Jinan Central Hospital

🇨🇳

Jinan, Shandong, China

Shandong Cancer Hospital

🇨🇳

Jinan, Shandong, China

Shanghai Chest Hospital

🇨🇳

Shanghai, Shanghai, China

Fudan University Shanghai Cancer Center

🇨🇳

Shanghai, Shanghai, China

Shanghai Pulmonary Hospital

🇨🇳

Shanghai, Shanghai, China

West China Hospital, Sichuan University

🇨🇳

Cheng Du, Sichuan, China

The Third People's Hospital of Chengdu (CDTPH)

🇨🇳

Chengdu, Sichuan, China

Sichuan Cancer hospital

🇨🇳

Chengdu, Sichuan, China

The Second People's Hospital of Neijiang

🇨🇳

Neijiang, Sichuan, China

Tianjin Medical University Cancer Institute & Hospital

🇨🇳

Tianjin, Tianjin, China

Zhejiang Provincial People's Hospital

🇨🇳

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital

🇨🇳

Hangzhou, Zhejiang, China

The Second Affiliated hospital of Zhejiang University school of medicine

🇨🇳

Hangzhou, Zhejiang, China

Taizhou Hospital of Zhejiang Province

🇨🇳

Linhai, Zhejiang, China

Nemocnice AGEL Ostrava - Vitkovice a.s.

🇨🇿

Ostrava, Ostrava Město, Czechia

Fakultni nemocnice Bulovka

🇨🇿

Prague, Praha 8, Czechia

Centre Antoine-Lacassagne

🇫🇷

Nice, Alpes-Maritimes, France

CHU Bordeaux Haut-Leveque

🇫🇷

Pessac, Aquitaine, France

Assistance Publique Hôpitaux de Marseille - Hôpital Nord

🇫🇷

Marseille, Bouches-du-Rhône, France

CHU de Toulouse - Hopital Larrey

🇫🇷

Toulouse, Haute-Garonne, France

Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou

🇫🇷

Rennes, Ille-et-Vilaine, France

Chu Grenoble Alpes

🇫🇷

La Tronche, Isère, France

Institut de Cancérologie de l'Ouest

🇫🇷

Saint Herblain, Loire-Atlantique, France

Hôpital Robert Schuman

🇫🇷

Vantoux, Lorraine, France

Institut Jean Godinot

🇫🇷

Reims, Marne, France

Centre Leon Berard

🇫🇷

Lyon Cedex08, Rhône-Alpes, France

Hospices Civils de Lyon - Hopital Louis Pradel

🇫🇷

Bron, Rhône, France

Gustave Roussy

🇫🇷

Villejuif, Val-de-Marne, France

Centre Hospitalier Universitaire de Poitiers

🇫🇷

Poitiers, Vienne, France

Institut Curie

🇫🇷

Paris, France

Groupe hospitalier Paris saint Joseph

🇫🇷

Paris, Île-de-France, France

Hôpital Européen Georges Pompidou

🇫🇷

Paris, Île-de-France, France

Thoraxklinik-Heidelberg gGmbH

🇩🇪

Heidelberg, Baden-Württemberg, Germany

Robert Bosch Krankenhaus GmbH

🇩🇪

Stuttgart, Baden-Württemberg, Germany

Universitaetsklinikum Tuebingen

🇩🇪

Tübingen, Baden-Württemberg, Germany

Onkologiezentrum Donauwörth

🇩🇪

Donauwörth, Bayern, Germany

Asklepios Fachkliniken München-Gauting

🇩🇪

Gauting, Bayern, Germany

Klinikverbund Allgäu gGmbH

🇩🇪

Kempten, Bayern, Germany

Klinikum Nürnberg Nord

🇩🇪

Nürnberg, Bayern, Germany

MV-Zentrum für Onkologie und Hämatologie

🇩🇪

Cologne, Nordrhein-Westfalen, Germany

Florence-Nightingale-Krankenhaus

🇩🇪

Düsseldorf, Nordrhein-Westfalen, Germany

Klinikum Köln-Merheim

🇩🇪

Köln, Nordrhein-Westfalen, Germany

Krankenhaus Martha-Maria Halle-Dölau

🇩🇪

Halle, Sachsen-Anhalt, Germany

Klinikum Chemnitz

🇩🇪

Chemnitz, Sachsen, Germany

St. Elisabeth-Krankenhaus Leipzig

🇩🇪

Leipzig, Sachsen, Germany

LungenClinic Grosshansdorf

🇩🇪

Grosshansdorf, Schleswig-Holstein, Germany

HELIOS Klinikum Erfurt

🇩🇪

Erfurt, Thüringen, Germany

Vivantes Klinikum im Friedrichshain - Landsberger Allee

🇩🇪

Berlin, Germany

Evangelische Lungenklinik Berlin

🇩🇪

Berlin, Germany

DRK Kliniken Berlin Mitte

🇩🇪

Berlin, Germany

Franziskus-Hospital Harderberg

🇩🇪

Georgsmarienhütte, Germany

Asklepios Klinik Harburg

🇩🇪

Hamburg, Germany

University Hospital of Patras

🇬🇷

Patras, Achaḯa, Greece

Agios Savvas Regional Cancer Hospital

🇬🇷

Athens, Attikí, Greece

Errikos Dunant Hospital Center

🇬🇷

Athens, Attikí, Greece

Thoracic General Hospital of Athens "I Sotiria"

🇬🇷

Athens, Attikí, Greece

University General Hospital of Heraklion

🇬🇷

Heraklion, Irakleío, Greece

Agios Loukas Clinic

🇬🇷

Thessaloniki, Kentrikí Makedonía, Greece

European Interbalkan Medical Center

🇬🇷

Thessaloniki, Thessaloníki, Greece

University General Hospital of Larissa

🇬🇷

Larissa, Thessalía, Greece

Farkasgyepui Tudogyogyintezet

🇭🇺

Farkasgyepu, Veszprém, Hungary

Országos Onkológiai Intézet

🇭🇺

Budapest, Hungary

Budapesti Uzsoki Utcai Kórház

🇭🇺

Budapest, Hungary

Savera Cancer & Multi Speciality Hospital

🇮🇳

Patna, Bihar, India

Rajiv Gandhi Cancer Institute And Research Centre

🇮🇳

New Delhi, Delhi, India

Hemato Oncology Clinic

🇮🇳

Ahmedabad, Gujarat, India

Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences

🇮🇳

Rohtak, Haryana, India

Galaxy Superspeciality Hospital

🇮🇳

Aurangabad, Maharashtra, India

Sir H. N. Reliance Foundation Hospital and Research Centre

🇮🇳

Mumbai, Maharashtra, India

Deenanath Mangeshkar Hospital & Research Centre

🇮🇳

Pune, Maharashtra, India

Medipoint Hospitals Pvt. Ltd.

🇮🇳

Pune, Maharashtra, India

Pacific Medical College & Hospital

🇮🇳

Udaipur, Rajasthan, India

Tata Memorial Centre - Homi Bhabha Cancer Hospital

🇮🇳

Varanasi, Uttar Pradesh, India

Meir Medical Center

🇮🇱

Kfar Saba, HaMerkaz, Israel

Sheba Medical Center

🇮🇱

Ramat Gan, HaMerkaz, Israel

Rambam Health Care Campus

🇮🇱

Haifa, HaTsafon, Israel

Shaare Zedek Medical Center

🇮🇱

Jerusalem, Yerushalayim, Israel

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

🇮🇹

Meldola, Emilia-Romagna, Italy

Samsun Medical Park Hastanesi

🇹🇷

Samsun, Turkey

ASST Grande Ospedale Metropolitano Niguarda

🇮🇹

Milan, Milano, Italy

Azienda Ospedaliera Dei Colli

🇮🇹

Naples, Napoli, Italy

Azienda Sanitaria Ospedaliera S Luigi Gonzaga

🇮🇹

Orbassano, Piemonte, Italy

Instituto Tumori Giovanni Paolo II

🇮🇹

Bari, Puglia, Italy

Istituto Nazionale Tumori Regina Elena

🇮🇹

Rome, Roma, Italy

Policlinico "G. Rodolico"

🇮🇹

Catania, Sicilia, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

🇮🇹

Verona, Veneto, Italy

Ospedale San Martino

🇮🇹

Genova, Italy

Aichi Cancer Center Hospital

🇯🇵

Nagoya, Aichi, Japan

National Cancer Center Hospital East

🇯🇵

Kashiwa, Chiba, Japan

Hokkaido University Hospital

🇯🇵

Sapporo, Hokkaido, Japan

Himeji Medical Center

🇯🇵

Himeji, Hyogo, Japan

Kanazawa University Hospital

🇯🇵

Kanazawa, Ishikawa, Japan

Kanagawa Cardiovascular and Respiratory Center

🇯🇵

Yokohama, Kanagawa, Japan

Kanagawa cancer center

🇯🇵

Yokohama, Kanagawa, Japan

Niigata Cancer Center Hospital

🇯🇵

Niigata-shi, Niigata, Japan

Kansai Medical University Hospital

🇯🇵

Hirakata, Osaka, Japan

Saitama Medical University International Medical Center

🇯🇵

Hidaka, Saitama, Japan

Shizuoka Cancer Center

🇯🇵

Nagaizumi-cho,Sunto-gun, Shizuoka, Japan

Tokyo Metropolitan Komagome Hospital

🇯🇵

Bunkyo ku, Tokyo, Japan

Juntendo University Hospital

🇯🇵

Bunkyo-ku, Tokyo, Japan

The Cancer Institute Hospital of JFCR

🇯🇵

Koto, Tokyo, Japan

Tottori University Hospital

🇯🇵

Yonago, Tottori, Japan

Kyushu University Hospital

🇯🇵

Fukuoka, Japan

University Hospital,Kyoto Prefectural University of Medicine

🇯🇵

Kyoto, Japan

Wakayama Medical University Hospital

🇯🇵

Wakayama, Japan

Chungbuk National University Hospital

🇰🇷

Cheongju-si, Chungcheongbuk-do [Chungbuk], Korea, Republic of

The Catholic University of Korea, Incheon St. Mary's Hospital

🇰🇷

Bupyeong-gu, Incheon-gwangyeoksi [Incheon], Korea, Republic of

Chonnam National University Hwasun Hospital

🇰🇷

Hwasun-gun, Jeonranamdo, Korea, Republic of

National Cancer Center

🇰🇷

Goyang-si, Kyǒnggi-do, Korea, Republic of

Seoul National University Bundang Hospital

🇰🇷

Seongnam, Kyǒnggi-do, Korea, Republic of

The Catholic University Of Korea St. Vincent's Hospital

🇰🇷

Suwon-si, Kyǒnggi-do, Korea, Republic of

Pusan National University Yangsan Hospital

🇰🇷

Yangsan, Kyǒngsangnam-do, Korea, Republic of

Pusan National University Hospital

🇰🇷

Busan, Pusan-Kwangyǒkshi, Korea, Republic of

Gangnam Severance Hospital, Yonsei University Health System

🇰🇷

Gangnam-gu, Seoul-teukbyeolsi [Seoul], Korea, Republic of

The Catholic University of Korea, Eunpyeong St. Mary's Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Haukeland Universitetssjukehus

🇳🇴

Bergen, Hordaland, Norway

Severance Hospital, Yonsei University Health System

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Konkuk University Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

The Catholic Univ. of Korea Seoul St. Mary's Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

The Catholic University of Korea, Yeouido St. Mary's Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Korea University Guro Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Keimyung University Dongsan Hospital

🇰🇷

Daegu, Taegu-Kwangyǒkshi, Korea, Republic of

Kyungpook National University Chilgok Hospital

🇰🇷

Deagu, Taegu-Kwangyǒkshi, Korea, Republic of

Yeungnam Univeristy Medical Center

🇰🇷

Nam-gu, Taegu-Kwangyǒkshi, Korea, Republic of

Ziekenhuis St. Jansdal

🇳🇱

Harderwijk, Gelderland, Netherlands

Amphia Ziekenhuis, locatie Breda Molengracht

🇳🇱

Breda, Noord-Brabant, Netherlands

ETZ Elisabeth

🇳🇱

Tilburg, Noord-Brabant, Netherlands

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)

🇳🇱

Amsterdam, Noord-Holland, Netherlands

Amsterdam UMC, locatie VUmc

🇳🇱

Amsterdam, Noord-Holland, Netherlands

Isala, locatie Zwolle

🇳🇱

Zwolle, Overijssel, Netherlands

St. Antonius Ziekenhuis, locatie Utrecht

🇳🇱

Utrecht, Netherlands

Sorlandet Sykehus Arendal

🇳🇴

Arendal, Aust-Agder, Norway

Drammen Sykehus, Vestre Viken HF

🇳🇴

Drammen, Buskerud, Norway

Sykehuset Innlandet HF Gjøvik

🇳🇴

Gjøvik, Oppland, Norway

Oslo Universitetssykehus Ullevål

🇳🇴

Oslo, Norway

Wielkopolskie Centrum Pulmonologii i Torakochirurgii

🇵🇱

Poznan, Wielkopolskie, Poland

One Day Med

🇵🇱

Szczecin, Zachodniopomorskie, Poland

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej

🇵🇱

Kielce, Świętokrzyskie, Poland

Centro Hospitalar E Universitário De Coimbra

🇵🇹

Coimbra, Portugal

Hospital da Luz Lisboa

🇵🇹

Lisboa, Portugal

Hospital CUF Porto

🇵🇹

Porto, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil, EPE

🇵🇹

Porto, Portugal

Lotus-Med

🇷🇴

Bucharest, București, Romania

SC Memorial Healthcare International SRL

🇷🇴

Bucharest, București, Romania

Ovidius Clinical Hospital OCH

🇷🇴

Ovidiu, Constanța, Romania

Institutul Oncologic

🇷🇴

Cluj, Romania

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica

🇸🇰

Banska Bystrica, Banskobystrický Kraj, Slovakia

Univerzitná nemocnica Bratislava - Nemocnica Ružinov

🇸🇰

Bratislava, Bratislavský Kraj, Slovakia

Vychodoslovensky Onkologicky ustav a.s.

🇸🇰

Kosice, Slovakia

CHUS - Hospital Clinico Universitario

🇪🇸

Santiago de Compostela, A Coruña [La Coruña], Spain

Hospital Universitari Son Espases

🇪🇸

Palma, Balears [Baleares], Spain

Parc de Salut Mar - Hospital del Mar

🇪🇸

Barcelona, Barcelona [Barcelona], Spain

Hospital Universitari Vall d'Hebron

🇪🇸

Barcelona, Barcelona [Barcelona], Spain

Instituto Catalan de Oncologia - Hospital Duran i Reynals

🇪🇸

Hospitalet, Barcelona [Barcelona], Spain

Hospital Clínic de Barcelona

🇪🇸

Barcelona, Catalunya [Cataluña], Spain

Hospital Jerez de la Frontera

🇪🇸

Jerez de la Frontera, Cádiz, Spain

Hospital Insular de Gran Canaria

🇪🇸

Las Palmas de Gran Canaria, Las Palmas, Spain

Hospital General Universitario Gregorio Marañon

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario Ramón y Cajal

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario Quironsalud Madrid

🇪🇸

Pozuelo de Alarcon, Madrid, Spain

Complejo Hospitalario de Navarra

🇪🇸

Pamplona, Navarra, Spain

Hospital Clinico de Valencia

🇪🇸

Valencia, Valenciana, Comunitat, Spain

Hospital Infanta Cristina

🇪🇸

Badajoz, Spain

H.R.U Málaga - Hospital General

🇪🇸

Málaga, Spain

Hospital Universitario Virgen Del Rocio

🇪🇸

Sevilla, Spain

Hospital Clínico Universitario Lozano Blesa

🇪🇸

Zaragoza, Spain

Sahlgrenska Universitetssjukhuset Östra

🇸🇪

Göteborg, Västra Götalands Län [se-14], Sweden

Kantonsspital Baden

🇨🇭

Baden, Switzerland

HFR Fribourg - Hôpital Cantonal

🇨🇭

Fribourg, Switzerland

UniversitätsSpital Zürich

🇨🇭

Zürich, Switzerland

Changhua Christian Hospital

🇨🇳

Changhua County, Changhua, Taiwan

Hualien Tzu Chi Medical Center

🇨🇳

Hualien City, Hualien, Taiwan

Chang Gung Memorial Hospital at Kaohsiung

🇨🇳

Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan

Far Eastern Memorial Hospital

🇨🇳

New Taipei City, New Taipei, Taiwan

New Taipei Municipal TuCheng Hospital

🇨🇳

New Taipei City, New Taipei, Taiwan

Chung Shan Medical University Hospital

🇨🇳

Taichung City, Taichung, Taiwan

Chi Mei Medical Center

🇨🇳

Tainan City, Tainan, Taiwan

Chi Mei Hospital - Liouying Branch

🇨🇳

Tainan City, Tainan, Taiwan

National Taiwan University Cancer Center (NTUCC)

🇨🇳

Taipei City, Taipei, Taiwan

National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region

🇨🇳

Douliu City, Yunlin, Taiwan

Buddhist Dalin Tzu Chi General Hospital

🇨🇳

Chiayi, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

🇨🇳

Kaohsiung, Taiwan

E-Da hospital

🇨🇳

Kaohsiung, Taiwan

Taichung Veterans General Hospital

🇨🇳

Taichung, Taiwan

National Cheng Kung University Hospital

🇨🇳

Tainan, Taiwan

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

🇨🇳

Taoyuan, Taiwan

Sakarya University School of Medicine

🇹🇷

Adapazarı, Sakarya, Turkey

Baskent University Dr. Turgut Noyan Research and Training Center

🇹🇷

Adana, Turkey

Adana City Hospital

🇹🇷

Adana, Turkey

Antalya Egitim ve Arastırma Hastanesi

🇹🇷

Antalya, Turkey

Trakya University

🇹🇷

Edirne, Turkey

Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

🇹🇷

Gaziantep, Turkey

İ.A.Ü VM Medical Park Florya Hastanesi

🇹🇷

Istanbul, Turkey

Marmara Universitesi Pendik Egitim Arastirma Hastanesi

🇹🇷

Istanbul, Turkey

Izmir Atatürk Training and Research Hospital

🇹🇷

Izmir, Turkey

University Hospitals Sussex NHS Foundation Trust

🇬🇧

East Sussex, Brighton And Hove, United Kingdom

Torbay Hospital

🇬🇧

Torquay, Devon, United Kingdom

Huddersfield Royal Infirmary

🇬🇧

Huddersfield, England, United Kingdom

Royal Marsden Hospital (Chelsea)

🇬🇧

London, Kensington And Chelsea, United Kingdom

Royal Marsden Hospital (Sutton)

🇬🇧

London, Sutton, United Kingdom

Heartlands Hospital

🇬🇧

Birmingham, United Kingdom

The Christie NHS Foundation Trust

🇬🇧

Manchester, United Kingdom

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