Expression and Distribution of Membrane-Organizing Extension Spike Protein (Moesin/ MSN) is Associated With Epithelial-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 主要终点
- Detection of Moesin in renal cell carcinoma
研究概览
简要总结
Renal cell carcinoma (RCC) is the most frequently occurring primary renal neoplasm. There are several histological variants of RCC that are associated with variable prognostic outcomes. Epithelial-mesenchymal transition (EMT) is a phenomenon in which the epithelial cells acquire some mesenchymal criteria as enhanced invasive potential. There are several cell surface molecules that are implicated in EMT. Moesin is one of these molecules that is involved in EMT, which is associated with enhanced invasive potential and poor prognosis. Targeting Moesin by novel therapeutic agents may prevent EMT and improve prognosis of patients with RCC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All cases of ccRCC.
- •Tissue blocks with material adequate for immunohistochemical evaluation.
- •All cases with accessible clinical data.
排除标准
- •Cases of renal neoplasms other than ccRCC.
- •Patients who received preoperative chemotherapy or radiotherapy.
- •Patients with ccRCC who were diagnosed by tru-cut biopsies only and didn't undergo radical operations.
- •Cases with insufficient/destructed material.
- •Patients with inadequate clinical data.
结局指标
主要结局
Detection of Moesin in renal cell carcinoma
时间窗: 6 months
different levels of moesin expression will be correlated with some tumor characteristics as patients' ages, sexes, tumor site, tumor grades, stages and nodal statuses.
次要结局
未报告次要终点
研究者
Maisa Hashem Mohammed
Maisa H Mohammed, MD
Sohag University