跳至主要内容
临床试验/NCT07443345
NCT07443345招募中不适用

Incidence of Postoperative Diaphragmatic Dysfunction in Pregnant Women With Preeclampsia With Severe Features Undergoing Cesarean Delivery: A Prospective Observational Study

Cairo University1 个研究点 分布在 1 个国家目标入组 52 人开始时间: 2026年3月9日最近更新:

试验速览

阶段
不适用
状态
招募中
入组人数
52
试验地点
1
主要终点
The incidence of postoperative diaphragmatic dysfunction

研究概览

简要总结

Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is defined by hypertension and involvement of multiple organ systems, including renal, hepatic, hematologic, and neurologic pathways. The interplay of endothelial dysfunction, capillary leakage, and disrupted fluid balance in these patients increases their susceptibility to perioperative pulmonary complications. Although respiratory complications in preeclampsia are clinically significant, the true incidence of postoperative diaphragmatic dysfunction in women with severe disease is not well established. Existing literature largely emphasizes general respiratory failure, pulmonary edema, or the need for mechanical ventilation, rather than specifically evaluating diaphragmatic performance with objective methods such as ultrasound. The current study sought to determine the incidence and identify risk factors for postoperative diaphragmatic dysfunction in women with severe preeclampsia following cesarean delivery.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Patients with severe preeclampsia undergoing cesarean section
  • Gestational age > 32 weeks

排除标准

  • • Age < 20 years.
  • Patients with neuromuscular diseases.
  • Patient refusal.
  • Contraindications to magnesium sulphate administration
  • Inability to obtain adequate ultrasound views

研究组 & 干预措施

Preeclampsia with severe features

diaphragmatic excursion evaluation

结局指标

主要结局

The incidence of postoperative diaphragmatic dysfunction

时间窗: Diaphragmatic excursion is measured before and 24 hours after surgery.

diaphragmatic dysfunction is defined as a mean diaphragmatic excursion of less than 10 mm

次要结局

  • Percentage of change in DE(24 hours after surgery)
  • Risk factors associated with postoperative diaphragmatic dysfunction(24 hours after surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mina Adolf Helmy

Doctor

Cairo University

研究点 (1)

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