IRCT20211110053031N1尚未招募2 期
Evaluation and comparison of efficacy of atropine eye drops and ipratropium bromide oral spray and amitriptyline tablet in the management of clozapine-induced sialorrhea in patients with refractory schizophrenia using the TNHS(Toronto Nocturnal in the management of clozapine-induced sialorrhea in patients with refractory schizophrenia using the TNHS(Toronto Nocturnal Hypersalivation) scale Hypersalivation) scale
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 1
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •Patients aged 18 to 65 years with a diagnosis of schizophrenia according to the DSM-V criteria
- •Patients should be receiving clozapine for at least 30 days
- •Patients should have a minimum score of 2 on the TNHS scale for sialorrhea
排除标准
- •Development of allergies or history of allergies to amitriptyline, atropine and ipratropium bromide
- •Has an underlying disease such as Parkinson's or cerebral palsy that causes sialorrhea
- •The patient has problems and comorbidities such as untreated constipation or urinary retention or bladder obstruction
- •Concomitant use of drugs such as tricyclic antidepressants and atropine and ipratropium bromide and other anticholinergic drugs
- •Breastfeeding and pregnancy
- •History of diseases such as myasthenia gravis, seizures, cardiac arrhythmias, glaucoma, pyloric obstruction, prostate hypertrophy, renal failure, severe autonomic dysfunction, mental retardation, and paralytic paralysis
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