IRCT20211110053031N1
Not yet recruiting
Phase 2
Evaluation and comparison of efficacy of atropine eye drops and ipratropium bromide oral spray and amitriptyline tablet in the management of clozapine-induced sialorrhea in patients with refractory schizophrenia using the TNHS(Toronto Nocturnal in the management of clozapine-induced sialorrhea in patients with refractory schizophrenia using the TNHS(Toronto Nocturnal Hypersalivation) scale Hypersalivation) scale
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Shiraz University of Medical Sciences
- Enrollment
- 1
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged 18 to 65 years with a diagnosis of schizophrenia according to the DSM\-V criteria
- •Patients should be receiving clozapine for at least 30 days
- •Patients should have a minimum score of 2 on the TNHS scale for sialorrhea
Exclusion Criteria
- •Development of allergies or history of allergies to amitriptyline, atropine and ipratropium bromide
- •Has an underlying disease such as Parkinson's or cerebral palsy that causes sialorrhea
- •The patient has problems and comorbidities such as untreated constipation or urinary retention or bladder obstruction
- •Concomitant use of drugs such as tricyclic antidepressants and atropine and ipratropium bromide and other anticholinergic drugs
- •Breastfeeding and pregnancy
- •History of diseases such as myasthenia gravis, seizures, cardiac arrhythmias, glaucoma, pyloric obstruction, prostate hypertrophy, renal failure, severe autonomic dysfunction, mental retardation, and paralytic paralysis
Outcomes
Primary Outcomes
Not specified
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