Henry Ford Heart Score Randomized Trial: Rapid Discharge of Patients Evaluated for Possible Myocardial Infarction
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Henry Ford Health System
- Enrollment
- 105
- Primary Endpoint
- Cost of hospitalization
Study Overview
Brief Summary
This was a prospective randomized, controlled trial designed to quantify the reduction in cost and length of stay of early discharge of emergency department patients evaluated for acute myocardial infarction, who are deemed to be low risk based on a modified HEART score (a score that incorporates troponin biomarker, ecg, patient characteristics, and physician clinical judgment).
Detailed Description
This was a prospective randomized, controlled trial conducted from February 2014 to May 2015 designed to quantify the reduction in cost and length of stay of early discharge of emergency department patients evaluated for acute myocardial infarction, in those deemed to be low risk based on a modified HEART score. Our study enrolled only those deemed low risk, as these are the patients we believe best served by utilization of the HEART score decision aid.
A total of 105 patients evaluated for AMI in the ED with a modified HEART score ≤ 3 (which includes cardiac troponin I < 0.04 ng/ml at 0 and 3 hours) were randomized to immediate discharge (n = 53) vs management in an observation unit with stress testing (n = 52).
The primary endpoints were 30-day total cost and length of stay. Secondary endpoints were all-cause death, nonfatal AMI, rehospitalization for evaluation of possible AMI, and coronary revascularization at 30 days.
That such an early discharge strategy would decrease cost and length of stay is intuitively expected; our goal was to quantify such a reduction.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 21 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •patients 21 years or older
- •patients who presented to the Emergency Department with symptoms suspicious for AMI.
- •patients for whom the ED physician's intention to send the patient to the observation unit for stress testing
Exclusion Criteria
- •Cardiac Troponin I > 0.04 ng/mL at 0 or 3 hours
- •clinical presentation warranting admission
- •inability or unwillingness to consent
- •trauma as etiology of presenting symptoms.
Outcomes
Primary Outcomes
Cost of hospitalization
Time Frame: 30 days
Total charges accrued during index hospitalization, as well as costs related to index hospitalization up to 30 days after index discharge
Length of stay
Time Frame: up to 1 week
Total length of stay of index hospitalization
Secondary Outcomes
- 30-day MACE(30 days after index hospitalization)
Investigators
Tiberio Frisoli
MD, Member of Heart and Vascular Institute in the Division of Cardiology
Henry Ford Health System