System Evaluation of Reactive Oxygen Metabolites in the Value of Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- The different levels of the ROMs among different groups
研究概览
简要总结
This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
详细描述
Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of COPD according to GOLD 2013
排除标准
- •A history of asthma or other chronic lung diseases Take Antioxidant therapy There are new or recurrent symptomatic myocardial ischemia, severe arrhythmia, cardiac insufficiency cerebrovascular disease Senile dementia or cognitive impairment cancer Severe liver and kidney and other viscera function insufficiency Language communication barriers Limb activity disorder The last 3 months participated in sports training
结局指标
主要结局
The different levels of the ROMs among different groups
时间窗: 3 years
Apply the analysis of variance to compare the different levels of ROMs among the four different groups
次要结局
- The differences of the ROMs among the different lung function levels in the stable stage of COPD group(3 years)
- The relevance of the ROMs with the lung function levels in the stable stage of COPD group(3 years)
- The relevance of the ROMs with the score of mMRC in the stable stage of COPD group(3 years)
- The relevance of the ROMs with the score of CAT in the stable stage of COPD group(3 years)
- The relevance of the ROMs with the numbers of exacerbation in the stable stage of COPD group(3 years)
研究者
Jie liu
Resident
Beijing Chao Yang Hospital